The original strategies developed by Helicobacter pylori to persistently colonise its host and
to deregulate its cellular functions make this bacterium an outstanding model to study host …

Autotransporters are the core component of a molecular nano-machine that delivers cargo
proteins across the outer membrane of Gram-negative bacteria. Part of the type V secretion …

Information about macromolecular structure of protein complexes and related cellular and
molecular mechanisms can assist the search for vaccines and drug development processes …

Cryo-electron microscopy (cryo-EM) has become a leading technology for determining
protein structures. Recent advances in this field have allowed for atomic resolution …

Group I introns are catalytic RNAs that coordinate two consecutive transesterification
reactions for self-splicing. To understand how the group I intron promotes catalysis and …

The Tetrahymena group I intron has been a key system in the understanding of RNA folding
and misfolding. The molecule folds into a long-lived misfolded intermediate (M) in vitro …

Introduction Helicobacter pylori causes, via the influence of several virulence factors,
persistent infection of the stomach, which leads to severe complications. Vacuolating …

Tetrahymena ribozyme is a group I intron, whose self-splicing is the result of two sequential
ester-transfer reactions. To understand how it facilitates catalysis in the first self-splicing …

Prokaryotes and viruses have fought a long battle against each other. Prokaryotes use
CRISPR–Cas-mediated adaptive immunity, while conversely, viruses evolve multiple anti …

Mycobacterium tuberculosis secretes the tuberculosis necrotizing toxin (TNT) to kill host
cells. Here, we show that the WXG100 proteins EsxE and EsxF are essential for TNT …