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The immune modules conserved across the tree of life: Towards a definition of ancestral immunity
Immune defence mechanisms exist across the tree of life in such diversity that prokaryotic
antiviral responses have historically been considered unrelated to eukaryotic immunity …
antiviral responses have historically been considered unrelated to eukaryotic immunity …
Innate immunity: the bacterial connection
Pathogens have fueled the diversification of intracellular defense strategies that collectively
define cell-autonomous innate immunity. In bacteria, innate immunity is manifested by a …
define cell-autonomous innate immunity. In bacteria, innate immunity is manifested by a …
Eukaryotic CD-NTase, STING, and viperin proteins evolved via domain shuffling, horizontal transfer, and ancient inheritance from prokaryotes
Animals use a variety of cell-autonomous innate immune proteins to detect viral infections
and prevent replication. Recent studies have discovered that a subset of mammalian …
and prevent replication. Recent studies have discovered that a subset of mammalian …
Bacterial homologs of innate eukaryotic antiviral defenses with anti-phage activity highlight shared evolutionary roots of viral defenses
Prokaryotes have evolved a multitude of defense systems to protect against phage
predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here …
predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here …
Structure-based inference of eukaryotic complexity in Asgard archaea
Asgard archaea played a key role in the origin of the eukaryotic cell. While previous studies
found that Asgard genomes encode diverse eukaryotic signature proteins (ESPs) …
found that Asgard genomes encode diverse eukaryotic signature proteins (ESPs) …
Genomic landscape of antiviral defense systems in prokaryotes and phages
J Li, J Gu, R **a, M Li - bioRxiv, 2024 - biorxiv.org
Prokaryotes and their viruses have co-evolved for billions of years, resulting in emergence of
numerous antiviral defense systems. With the development of bioinformatic technologies …
numerous antiviral defense systems. With the development of bioinformatic technologies …
Research briefing
A Bernheim, H Shomar - nature.com
Proteins that are involved in immunity rapidly evolve to adapt to pathogens. However, some
eukaryotic immune proteins have been shown to originate from bacterial antiphage systems …
eukaryotic immune proteins have been shown to originate from bacterial antiphage systems …