Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

Telomeres play a central role in cell fate and aging by adjusting the cellular response to
stress and growth stimulation on the basis of previous cell divisions and DNA damage. At …

The natural ends of linear chromosomes require unique genetic and structural adaptations
to facilitate the protection of genetic material. This is achieved by the sequestration of the …

The article presents the guideline for the diagnosis and management of aplastic anaemia. It
aims to provide healthcare professionals with clear guidance on the diagnosis and …

The inherited marrow failure syndromes are a diverse set of genetic disorders characterized
by hematopoietic aplasia and cancer predisposition. The clinical phenotypes are highly …

ABSTRACT Introduction: Telomere biology disorders (TBDs) encompass a group of
illnesses caused by germline mutations in genes regulating telomere maintenance, resulting …

Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal
bodies, and telomerase is thought to be recruited to telomeres through interactions with …

Androgens have been used in the treatment of bone marrow failure syndromes without a
clear understanding of their mechanism of action. Blood counts of patients with dyskeratosis …

Genetic mutations that affect telomerase function or telomere maintenance result in a variety
of diseases collectively called telomeropathies. This wide spectrum of disorders, which …

Patients with dyskeratosis congenita (DC), a heterogeneous inherited bone marrow failure
syndrome, have abnormalities in telomere biology, including very short telomeres and …