Regulatory pathways and drugs associated with ferroptosis in tumors
D Wang, L Tang, Y Zhang, G Ge, X Jiang, Y Mo… - Cell Death & …, 2022 - nature.com
Ferroptosis is a type of cell death that depends on iron and reactive oxygen species (ROS).
The accumulation of iron and lipid peroxidation primarily initiates oxidative membrane …
The accumulation of iron and lipid peroxidation primarily initiates oxidative membrane …
Mitochondrial metabolic signatures in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide.
HCC progression and metastasis are closely related to altered mitochondrial metabolism …
HCC progression and metastasis are closely related to altered mitochondrial metabolism …
NUPR1 is a critical repressor of ferroptosis
Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …
NUPR1 promotes the proliferation and metastasis of oral squamous cell carcinoma cells by activating TFE3-dependent autophagy
T Fan, X Wang, S Zhang, P Deng, Y Jiang… - Signal transduction and …, 2022 - nature.com
Oral squamous cell carcinoma (OSCC) is the most common type of oral malignancy, and
metastasis accounts for the poor prognosis of OSCC. Autophagy is considered to facilitate …
metastasis accounts for the poor prognosis of OSCC. Autophagy is considered to facilitate …
Differential activation of the transcription factor IRF1 underlies the distinct immune responses elicited by type I and type III interferons
Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …
Targeting intrinsically disordered proteins involved in cancer
Intrinsically disordered proteins (IDPs) do not have a well-defined structure under
physiological conditions, but they have key roles in cell signaling and regulation, and they …
physiological conditions, but they have key roles in cell signaling and regulation, and they …
NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner
C Huang, P Santofimia-Castaño, X Liu, Y **a… - Cell death …, 2021 - nature.com
Ferroptosis is an iron-dependent cell death characterized by the accumulation of
hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces …
hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces …
[HTML][HTML] Spatial maps of hepatocellular carcinoma transcriptomes reveal spatial expression patterns in tumor immune microenvironment
Y Wang, S Yuan, H Jiang, Z Li, H Yin, J Tan, Z Dai… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Hepatocellular carcinoma (HCC) is a highly heterogeneous and malignant
disease with the complex immune microenvironment, which ultimately influence clinic …
disease with the complex immune microenvironment, which ultimately influence clinic …
Effects of TP53 mutations and miRs on immune responses in the tumor microenvironment important in pancreatic cancer progression
JA McCubrey, LV Yang, SL Abrams, LS Steelman… - Cells, 2022 - mdpi.com
Approximately 90% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC).
PDAC is the fourth leading cause of cancer death world-wide. Therapies for PDAC are …
PDAC is the fourth leading cause of cancer death world-wide. Therapies for PDAC are …
NUPR1: a critical regulator of the antioxidant system
C Huang, P Santofimia-Castaño, J Iovanna - Cancers, 2021 - mdpi.com
Simple Summary Nuclear protein 1 (NUPR1) is activated in cellular stress and is expressed
at high levels in cancer cells. Much evidence has been gathered supporting its critical role in …
at high levels in cancer cells. Much evidence has been gathered supporting its critical role in …