During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling
of their cytoskeleton and membranes. For cell division to occur, chromosomes must be …

Dynamic protein phosphorylation and dephosphorylation are essential regulatory
mechanisms that ensure proper cellular signaling and biological functions. Deregulation of …

The midbody is an organelle assembled at the intercellular bridge between the two daughter
cells at the end of mitosis. It controls the final separation of the daughter cells and has been …

Mitosis requires extensive rearrangement of cellular architecture and of subcellular
structures so that replicated chromosomes can bind correctly to spindle microtubules and …

Actin is the most abundant protein in almost all the eukaryotic cells. Actin amino acid
sequences are highly conserved and have not changed a lot during the progress of …

Protein phosphorylation is a ubiquitous post-translational modification used to regulate
cellular processes and proteome architecture by modulating protein-protein interactions …

We recently developed a heterobifunctional approach [phosphorylation targeting chimeras
(PhosTACs)] to achieve the targeted protein dephosphorylation (TPDephos). Here, we …

Subcellular location and activation of Tank Binding Kinase 1 (TBK1) govern precise
progression through mitosis. Either loss of activated TBK1 or its sequestration from the …

Protein phosphorylation on serine and threonine residues is a widely distributed post-
translational modification on proteins that acts to regulate their function. Phosphoprotein …

Human Perrault syndrome (PRLTS) is autosomal, recessively inherited, and characterized
by ovarian insufficiency with hearing loss. Among the genetic causes are mutations of matrix …