Molecular mechanisms of opioid receptor-dependent signaling and behavior
Opioid receptors have been targeted for the treatment of pain and related disorders for
thousands of years, and remain the most widely used analgesics in the clinic. Mu (μ), kappa …
thousands of years, and remain the most widely used analgesics in the clinic. Mu (μ), kappa …
Nociceptin/orphanin FQ receptor structure, signaling, ligands, functions, and interactions with opioid systems
The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently
discovered member of the opioid receptor family and, together with its endogenous ligand …
discovered member of the opioid receptor family and, together with its endogenous ligand …
[HTML][HTML] Isoforms of mammalian adenylyl cyclase: multiplicities of signaling
RK Sunahara, R Taussig - Molecular interventions, 2002 - triggered.edina.clockss.org
Mechanistic descriptions of cAMP production have evolved significantly since the 1960s
when Sutherland and Rall hypothesized the existence of a single polypeptide that would …
when Sutherland and Rall hypothesized the existence of a single polypeptide that would …
The mechanisms involved in morphine addiction: an overview
J Listos, M Łupina, S Talarek, A Mazur… - International journal of …, 2019 - mdpi.com
Opioid use disorder is classified as a chronic recurrent disease of the central nervous
system (CNS) which leads to personality disorders, co-morbidities and premature death. It …
system (CNS) which leads to personality disorders, co-morbidities and premature death. It …
Splicing of α1A subunit gene generates phenotypic variants of P-and Q-type calcium channels
P-type and Q-type calcium channels mediate neurotransmitter release at many synapses in
the mammalian nervous system. The α 1A calcium channel has been implicated in the …
the mammalian nervous system. The α 1A calcium channel has been implicated in the …
[HTML][HTML] G-proteins as transducers in transmembrane signalling
S Offermanns - Progress in biophysics and molecular biology, 2003 - Elsevier
The G-protein-mediated signalling system has evolved as one of the most widely used
transmembrane signalling mechanisms in mammalian organisms. All mammalian cells …
transmembrane signalling mechanisms in mammalian organisms. All mammalian cells …
[HTML][HTML] Regulation of CaV2 calcium channels by G protein coupled receptors
Voltage gated calcium channels (Ca2+ channels) are key mediators of depolarization
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …
induced calcium influx into excitable cells, and thereby play pivotal roles in a wide array of …
Molecular mechanisms of opioid tolerance: From opioid receptors to inflammatory mediators
J Zhou, R Ma, Y **, J Fang, J Du… - Experimental and …, 2021 - spandidos-publications.com
Opioids are considered the most effective analgesics for the treatment of both acute and
chronic pain. However, prolonged opioid use can induce a certain level of tolerance to its …
chronic pain. However, prolonged opioid use can induce a certain level of tolerance to its …
Analysis of calcium channels in single spines using optical fluctuation analysis
Most synapses form on small, specialized postsynaptic structures known as dendritic spines.
The influx of Ca2+ ions into such spines—through synaptic receptors and voltage-sensitive …
The influx of Ca2+ ions into such spines—through synaptic receptors and voltage-sensitive …
Altered pain responses in mice lacking α1E subunit of the voltage-dependent Ca2+ channel
H Saegusa, T Kurihara, S Zong… - Proceedings of the …, 2000 - National Acad Sciences
α1 subunit of the voltage-dependent Ca2+ channel is essential for channel function and
determines the functional specificity of various channel types. α1E subunit was originally …
determines the functional specificity of various channel types. α1E subunit was originally …