Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Emerging functions of thrombospondin-1 in immunity

S Kaur, DD Roberts - Seminars in cell & developmental biology, 2024 - Elsevier
Thrombospondin-1 is a secreted matricellular glycoprotein that modulates cell behavior by
interacting with components of the extracellular matrix and with several cell surface …

The structural basis for CD36 binding by the malaria parasite

FL Hsieh, L Turner, JR Bolla, CV Robinson… - Nature …, 2016 - nature.com
CD36 is a scavenger receptor involved in fatty acid metabolism, innate immunity and
angiogenesis. It interacts with lipoprotein particles and facilitates uptake of long chain fatty …

Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

F Lennartz, Y Adams, A Bengtsson, RW Olsen… - Cell host & …, 2017 - cell.com
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …

Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …

Immune mechanisms in malaria: new insights in vaccine development

EM Riley, VA Stewart - Nature medicine, 2013 - nature.com
Early data emerging from the first phase 3 trial of a malaria vaccine are raising hopes that a
licensed vaccine will soon be available for use in endemic countries, but given the relatively …

PfEMP1–a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis

L Hviid, ATR Jensen - Advances in parasitology, 2015 - Elsevier
Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …

A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells

A Claessens, Y Adams, A Ghumra… - Proceedings of the …, 2012 - pnas.org
Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum.
The pathology of cerebral malaria is characterized by the accumulation of infected …

A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells

M Avril, AK Tripathi, AJ Brazier, C Andisi… - Proceedings of the …, 2012 - pnas.org
Cerebral malaria (CM) is a deadly complication of Plasmodium falciparum infection, but
specific interactions involved in cerebral homing of infected erythrocytes (IEs) are poorly …

Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria

Y Adams, RW Olsen, A Bengtsson… - Journal of Experimental …, 2021 - rupress.org
Cerebral malaria (CM) is caused by the binding of Plasmodium falciparum–infected
erythrocytes (IEs) to the brain microvasculature, leading to inflammation, vessel occlusion …