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Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …
Emerging functions of thrombospondin-1 in immunity
S Kaur, DD Roberts - Seminars in cell & developmental biology, 2024 - Elsevier
Thrombospondin-1 is a secreted matricellular glycoprotein that modulates cell behavior by
interacting with components of the extracellular matrix and with several cell surface …
interacting with components of the extracellular matrix and with several cell surface …
The structural basis for CD36 binding by the malaria parasite
CD36 is a scavenger receptor involved in fatty acid metabolism, innate immunity and
angiogenesis. It interacts with lipoprotein particles and facilitates uptake of long chain fatty …
angiogenesis. It interacts with lipoprotein particles and facilitates uptake of long chain fatty …
Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria
Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …
when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display …
Pathogenicity and virulence of malaria: Sticky problems and tricky solutions
IS Walker, SJ Rogerson - Virulence, 2023 - Taylor & Francis
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …
each year, concentrated in Africa and in young children, but much of the world's population …
Immune mechanisms in malaria: new insights in vaccine development
EM Riley, VA Stewart - Nature medicine, 2013 - nature.com
Early data emerging from the first phase 3 trial of a malaria vaccine are raising hopes that a
licensed vaccine will soon be available for use in endemic countries, but given the relatively …
licensed vaccine will soon be available for use in endemic countries, but given the relatively …
PfEMP1–a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis
L Hviid, ATR Jensen - Advances in parasitology, 2015 - Elsevier
Plasmodium falciparum causes the most severe form of malaria and is responsible for
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …
essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes …
A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells
Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum.
The pathology of cerebral malaria is characterized by the accumulation of infected …
The pathology of cerebral malaria is characterized by the accumulation of infected …
A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells
Cerebral malaria (CM) is a deadly complication of Plasmodium falciparum infection, but
specific interactions involved in cerebral homing of infected erythrocytes (IEs) are poorly …
specific interactions involved in cerebral homing of infected erythrocytes (IEs) are poorly …
Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria
Y Adams, RW Olsen, A Bengtsson… - Journal of Experimental …, 2021 - rupress.org
Cerebral malaria (CM) is caused by the binding of Plasmodium falciparum–infected
erythrocytes (IEs) to the brain microvasculature, leading to inflammation, vessel occlusion …
erythrocytes (IEs) to the brain microvasculature, leading to inflammation, vessel occlusion …