Human cytomegalovirus (HCMV) expresses a variety of viral regulatory proteins that
undergo close interaction with host factors including viral-cellular multiprotein complexes …

Background Nuclear replication represents a common hallmark of herpesviruses achieved
by a number of sequentially unrolled regulatory processes. A rate‐limiting step is provided …

The host restriction factor sterile alpha motif and histidine–aspartate domain-containing
protein 1 (SAMHD1) is an important component of the innate immune system. By regulating …

The nuclear phase of herpesvirus replication is regulated through the formation of regulatory
multi-component protein complexes. Viral genomic replication is followed by nuclear capsid …

Infection with human cytomegalovirus (HCMV) is a serious medical problem, particularly in
immunocompromised individuals and neonates. The success of (val) ganciclovir therapy is …

The assembly of human cytomegalovirus (HCMV) virions is an orchestrated process that
requires, as an essential prerequisite, the complex crosstalk between viral structural …

Introduction Congenital cytomegalovirus (HCMV) infection may cause significant fetal
malformation and in severe cases fetal and neonatal death. Fetal injury may be caused …

Herpesviruses thymidine kinase (TK) and protein kinase (PK) allow the activation of
nucleoside analogues used in anti-herpesvirus treatments. Mutations emerging in these two …

The complex host interaction network of human cytomegalovirus (HCMV) involves the
regulatory protein kinase pUL97, which represents a viral cyclin-dependent kinase (CDK) …

Human cytomegalovirus (HCMV) is a common β-herpesvirus causing life-long latent
infections. HCMV replication interferes with cell cycle regulation in host cells because the …