Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Central nervous system (CNS) infections including meningitis and encephalitis, resulting
from the blood-borne spread of specific microorganisms, provoke nervous tissue damage …

This study investigates the cellular origin and tissue heterogeneity in bipolar disorder (BD)
by integrating multiomics data. Four distinct datasets were employed, including single-cell …

Glial dysfunction is a major pathophysiological feature of mood disorders. While altered
astrocyte (AS) and oligodendrocyte-lineage (OL) functions have been associated with …

Mature myelinating oligodendrocytes, the cells that produce the myelin sheath that insulates
axons in the central nervous system, have distinct energetic and metabolic requirements …

The X-linked form of Charcot-Marie-Tooth disease (CMTX1) is the second most common
form of CMT. In this study we used CRISPR/Cas9 to develop new “knock-in” models of …

Accumulating evidence has shown the importance of glial cells in the neurobiology of
bipolar disorder. Activated microglia and inflammatory cytokines have been pointed out as …

Connexins are members of a family of integral membrane proteins that provide a pathway
for both electrical and metabolic coupling between cells. Astroglia express connexin 30 …

Drug-induced organ toxicity/injury, especially in the liver, kidney, and gastrointestinal tract, is
a systematic disorder that causes oxidative stress formation and inflammation resulting in …

Charcot-Marie-Tooth disease type 2A (CMT2A) is the most common hereditary axonal
neuropathy caused by mutations in MFN2 encoding Mitofusin-2, a multifunctional protein …