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Artificial intelligence for natural product drug discovery
Developments in computational omics technologies have provided new means to access
the hidden diversity of natural products, unearthing new potential for drug discovery. In …
the hidden diversity of natural products, unearthing new potential for drug discovery. In …
Peptidomics
Peptides are biopolymers, typically consisting of 2–50 amino acids. They are biologically
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …
produced by the cellular ribosomal machinery or by non-ribosomal enzymes and …
Statistical analysis of feature-based molecular networking results from non-targeted metabolomics data
Feature-based molecular networking (FBMN) is a popular analysis approach for liquid
chromatography–tandem mass spectrometry-based non-targeted metabolomics data. While …
chromatography–tandem mass spectrometry-based non-targeted metabolomics data. While …
Untargeted metabolomics analysis based on LC-IM-QTOF-MS for discriminating geographical origin and vintage of Chinese red wine
Z Wang, X Chen, Q Liu, L Zhang, S Liu, Y Su… - Food Research …, 2023 - Elsevier
Identifying wine geographical origin and vintage is vital due to the abundance of fraudulent
activity associated with wine mislabeling of region and vintage. In this study, an untargeted …
activity associated with wine mislabeling of region and vintage. In this study, an untargeted …
Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products
Covering: 1995 to 2023 Advances in bioanalytical methods, particularly mass spectrometry,
have provided valuable molecular insights into the mechanisms of life. Non-targeted …
have provided valuable molecular insights into the mechanisms of life. Non-targeted …
Leptochelins A–C, Cytotoxic Metallophores Produced by Geographically Dispersed Leptothoe Strains of Marine Cyanobacteria
Metals are important cofactors in the metabolic processes of cyanobacteria, including
photosynthesis, cellular respiration, DNA replication, and the biosynthesis of primary and …
photosynthesis, cellular respiration, DNA replication, and the biosynthesis of primary and …
Progress and challenges in exploring aquatic microbial communities using non-targeted metabolomics
Advances in bioanalytical technologies are constantly expanding our insights into complex
ecosystems. Here, we highlight strategies and applications that make use of non-targeted …
ecosystems. Here, we highlight strategies and applications that make use of non-targeted …
A survey of recently discovered naturally occurring organohalogen compounds
GW Gribble - Journal of Natural Products, 2024 - ACS Publications
The discovery of naturally occurring organohalogen compounds has increased
astronomically in the 55 years since they were first discovered─ from fewer than 50 in 1968 …
astronomically in the 55 years since they were first discovered─ from fewer than 50 in 1968 …
Multiplexed screening of thousands of natural products for protein–ligand binding in native mass spectrometry
GTH Nguyen, JL Bennett, S Liu… - Journal of the …, 2021 - ACS Publications
The structural diversity of natural products offers unique opportunities for drug discovery, but
challenges associated with their isolation and screening can hinder the identification of drug …
challenges associated with their isolation and screening can hinder the identification of drug …
Recent advances in the engineering and electrochemical applications of amorphous-based nanomaterials: A comprehensive review
L Yi, Y Zhang, K Nie, B Li, Y Yuan, Z Liu… - Coordination Chemistry …, 2024 - Elsevier
Phase engineering of the nanomaterials (PEN) strategy has been proposed to tune the
structure and properties of nanomaterials, which has significantly broadened the application …
structure and properties of nanomaterials, which has significantly broadened the application …