Designing drug delivery systems for cell therapy

LLW Wang, Y Gao, Z Feng, DJ Mooney… - Nature Reviews …, 2024 - nature.com
Cell therapies, such as immune cell and stem cell therapies, are being preclinically and
clinically explored for the treatment of various diseases, but are often limited by low efficacy …

Nano/genetically engineered cells for immunotherapy

J Shen, Y Zhou, L Yin - BMEMat, 2024 - Wiley Online Library
Immunotherapy has recently emerged as a promising therapeutic modality for the treatment
of various diseases such as cancer, inflammation, autoimmune diseases, and infectious …

Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy

N Kumbhojkar, S Prakash, T Fukuta… - Nature Biomedical …, 2024 - nature.com
Tumour-associated neutrophils can exert antitumour effects but can also assume a pro-
tumoural phenotype in the immunosuppressive tumour microenvironment. Here we show …

Micro/nano system-mediated local treatment in conjunction with immune checkpoint inhibitor against advanced-Stage malignant melanoma

L Tang, H Liu, Y Yin, T Pan, C Fu, Y Cao, Y Mei… - Chemical Engineering …, 2024 - Elsevier
Tumor relapse and metastasis become a big challenge in treating malignant melanoma
because conventional therapeutic options often fail to eradicate the tumor residue after …

Backpack-mediated anti-inflammatory macrophage cell therapy for the treatment of traumatic brain injury

N Kapate, R Liao, RL Sodemann, T Stinson… - PNAS …, 2024 - academic.oup.com
Traumatic brain injury (TBI) is a debilitating disease with no current therapies outside of
acute clinical management. While acute, controlled inflammation is important for debris …

Combination of Chemical and Mechanical Tumor Immunomodulation Using Cavitating Mesoporous Silica Nanoparticles

TR Ausec, LL Carr, TB Alina, NB Day… - ACS applied nano …, 2024 - ACS Publications
Combinatorial methods to repolarize tumor-associated macrophages from anti-inflammatory
to pro-inflammatory phenotypes offer a promising route for cancer immunotherapy. However …

pH‐Sensitive Magnetic Nanoparticle‐Mediated Natural‐Killer‐Cell‐Based Microrobots for Dual‐Targeted Delivery and Induction of Pro‐Inflammatory Macrophage …

VD Nguyen, J Park, S Choi, KT Nguyen, H Kim… - Small …, 2024 - Wiley Online Library
Adoptive cell therapy using natural killer (NK) cells emerges as the next‐generation cancer
immunotherapy. Based on the intrinsic capability of direct cancer cell necrosis without prior …

Reprogramming Dysfunctional Dendritic Cells by a Versatile Catalytic Dual Oxide Antigen-Captured Nanosponge for Remotely Enhancing Lung Metastasis …

MR Chiang, CW Hsu, WC Pan, NT Tran, YS Lee… - ACS …, 2024 - ACS Publications
Dendritic cells (DCs) play a crucial role in initiating antitumor immune responses. However,
in the tumor environment, dendritic cells often exhibit impaired antigen presentation and …

Mechanoimmune-Driven Backpack Sustains Dendritic Cell Maturation for Synergistic Tumor Radiotherapy

H Yu, Z Liu, H Guo, X Hu, Y Wang, X Cheng… - ACS …, 2024 - ACS Publications
Cell backpacks present significant potential in both therapeutic and diagnostic applications,
making it essential to further explore their interactions with host cells. Current evidence …

Dendritic Cell Immune Modulation via Polyphenol Membrane Coatings

ME Janes, KS Park, AP Gottlieb, A Curreri… - … Applied Materials & …, 2024 - ACS Publications
Cellular hitchhiking is an emerging strategy for the in vivo control of adoptively transferred
immune cells. Hitchhiking approaches are primarily mediated by adhesion of nano and …