Cognition in multiple sclerosis: State of the field and priorities for the future

JF Sumowski, R Benedict, C Enzinger, M Filippi… - Neurology, 2018 - AAN Enterprises
Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis
(MS), especially deficits in episodic memory and processing speed. The field aims to (1) …

Validity of the Symbol Digit Modalities Test as a cognition performance outcome measure for multiple sclerosis

RHB Benedict, J DeLuca, G Phillips… - Multiple Sclerosis …, 2017 - journals.sagepub.com
Cognitive and motor performance measures are commonly employed in multiple sclerosis
(MS) research, particularly when the purpose is to determine the efficacy of treatment. The …

Identifying the distinct cognitive phenotypes in multiple sclerosis

E De Meo, E Portaccio, A Giorgio, L Ruano… - JAMA …, 2021 - jamanetwork.com
Importance Cognitive impairment is a common and disabling feature of multiple sclerosis
(MS), but a precise characterization of cognitive phenotypes in patients with MS is lacking …

Clinical and imaging assessment of cognitive dysfunction in multiple sclerosis

MA Rocca, MP Amato, N De Stefano… - The Lancet …, 2015 - thelancet.com
In patients with multiple sclerosis (MS), grey matter damage is widespread and might
underlie many of the clinical symptoms, especially cognitive impairment. This relation …

Treatment and management of cognitive dysfunction in patients with multiple sclerosis

J DeLuca, ND Chiaravalloti, BM Sandroff - Nature Reviews Neurology, 2020 - nature.com
Cognitive impairment is a common and devastating manifestation of multiple sclerosis (MS).
Although disease-modifying therapies have been efficacious for reducing relapse rates in …

Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosis

YC Learmonth, RW Motl, BM Sandroff, JH Pula… - BMC neurology, 2013 - Springer
Abstract Background The Patient Determined Disease Steps (PDDS) is a promising patient-
reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited …

Cognitive impairment in multiple sclerosis

ND Chiaravalloti, J DeLuca - The Lancet Neurology, 2008 - thelancet.com
Multiple sclerosis (MS) is a progressive disease of the CNS that is characterised by
widespread lesions in the brain and spinal cord. MS results in motor, cognitive, and …

Oops!': performance correlates of everyday attentional failures in traumatic brain injured and normal subjects

IH Robertson, T Manly, J Andrade, BT Baddeley… - Neuropsychologia, 1997 - Elsevier
Insufficient attention to tasks can result in slips of action as automatic, unintended action
sequences are triggered inappropriately. Such slips arise in part from deficits in sustained …

Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction

SM Rao, GJ Leo, L Bernardin, F Unverzagt - Neurology, 1991 - AAN Enterprises
Previous frequency estimates of cognitive dysfunction in multiple sclerosis have ranged from
54 to 65 percent. These studies may overestimate the frequency in the general MS …

Brain MRI atrophy quantification in MS: from methods to clinical application

MA Rocca, M Battaglini, RHB Benedict, N De Stefano… - Neurology, 2017 - AAN Enterprises
Patients with the main clinical phenotypes of multiple sclerosis (MS) manifest varying
degrees of brain atrophy beyond that of normal aging. Assessment of atrophy helps to …