[HTML][HTML] Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblasts

Y Dai, X Xu, X Huo, MM Faas - Ecotoxicology and Environmental Safety, 2023 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are a group of persistent organic pollutants that
are carcinogenic, mutagenic, endocrine-toxic, and immunotoxic. PAHs can be found in …

Spontaneous preterm birth: Involvement of multiple feto-maternal tissues and organ systems, differing mechanisms, and pathways

MS Vidal Jr, RCV Lintao, MEL Severino… - Frontiers in …, 2022 - frontiersin.org
Survivors of preterm birth struggle with multitudes of disabilities due to improper in utero
programming of various tissues and organ systems contributing to adult-onset diseases at a …

circRNA mediates silica-induced macrophage activation via HECTD1/ZC3H12A-dependent ubiquitination

Z Zhou, R Jiang, X Yang, H Guo, S Fang… - …, 2018 - pmc.ncbi.nlm.nih.gov
Rationale: Phagocytosis of silicon dioxide (SiO2) into lung cells causes an inflammatory
cascade that results in fibroblast proliferation and migration, followed by fibrosis. Circular …

BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis

F Louwen, NN Kreis, A Ritter, A Friemel… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND The key oncogene B-cell lymphoma 6 (BCL6) drives malignant progression
by promoting proliferation, overriding DNA damage checkpoints and blocking cell terminal …

Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME

Z Zhao, Q Li, U Ashraf, M Yang, W Zhu, J Gu, Z Chen… - Elife, 2022 - elifesciences.org
Zika virus (ZIKV) can be transmitted from mother to fetus during pregnancy, causing adverse
fetal outcomes. Several studies have indicated that ZIKV can damage the fetal brain directly; …

Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism

F Wang, LMR Ferreira, A Mazzanti, H Yu, B Gu… - Journal of Reproductive …, 2024 - Elsevier
Implantation and maintenance of pregnancy involve intricate immunological processes that
enable the develo** fetus to coexist with the maternal immune system. Progesterone, a …

Co-culture of JEG-3, BeWo and syncBeWo cell lines with adrenal H295R cell line: an alternative model for examining endocrine and metabolic properties of the …

E Drwal, A Rak, E Gregoraszczuk - Cytotechnology, 2018 - Springer
Monocultures of different placental cells are used for many physiological and toxicological
studies; however, they are not a true reflection of the interaction between placenta and fetus …

Endometrial changes in estrogen and progesterone receptor expression during implantation in an oocyte donation program

E Klonos, P Katopodis, E Karteris… - Experimental and …, 2020 - spandidos-publications.com
Implantation is the final and most important stage of embryogenesis and is of paramount
importance in achieving a successful pregnancy. Progesterone and estrogen are steroid …

Involvement of the endocrine-disrupting chemical bisphenol A (BPA) in human placentation

SC de Aguiar Greca, I Kyrou, R Pink… - Journal of clinical …, 2020 - mdpi.com
Background: Endocrine-disrupting chemicals (EDCs) are environmental chemicals/toxicants
that humans are exposed to, interfering with the action of multiple hormones. Bisphenol A …

Plasminogen activator inhibitor 1 RNA-binding protein interacts with progesterone receptor membrane component 1 to regulate progesterone's ability to maintain the …

JJ Peluso, A Yuan, X Liu, V Lodde - Biology of reproduction, 2013 - academic.oup.com
Progesterone receptor membrane component 1 (PGRMC1) mediates the antiapoptotic
action of progesterone (P4). PGRMC1 interacts with plasminogen activator inhibitor 1 RNA …