Urea-based anticancer agents. Exploring 100-years of research with an eye to the future
R Listro, G Rossino, F Piaggi, FF Sonekan… - Frontiers in …, 2022 - frontiersin.org
Suramin was the first urea-based drug to be approved in clinic, and in the following century
a number of milestone drugs based on this scaffold were developed. Indeed, urea soon …
a number of milestone drugs based on this scaffold were developed. Indeed, urea soon …
[HTML][HTML] Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function
I Boniardi, A Corona, J Basquin, C Basquin, J Milia… - Virus Research, 2023 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic is fading, however its
etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues …
etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues …
Synthesis of Novel Suramin Analogs With Anti-Proliferative Activity via FGF1 and FGFRD2 Blockade
A promising approach in cancer therapy is the inhibition of cell proliferation using small
molecules. In this study, we report the synthesis of suramin derivatives and their …
molecules. In this study, we report the synthesis of suramin derivatives and their …
[HTML][HTML] A review of potential therapeutic strategies for COVID-19
J Meng, R Li, Z Zhang, J Wang, Q Huang, D Nie, K Fan… - Viruses, 2022 - mdpi.com
Coronavirus disease 2019 is a rather heterogeneous disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The ongoing pandemic is a global threat …
respiratory syndrome coronavirus 2 (SARS-CoV-2). The ongoing pandemic is a global threat …
The Anti-Cancer Activity of Pentamidine and Its Derivatives (WLC-4059) Is through Blocking the Interaction between S100A1 and RAGE V Domain
The S100A1 protein in humans is a calcium-binding protein. Upon Ca2+ binding to S100A1
EF-hand motifs, the conformation of S100A1 changes and promotes interactions with target …
EF-hand motifs, the conformation of S100A1 changes and promotes interactions with target …
[CITATION][C] Mitogen: Activators of Cell Proliferation Signaling
Z West - optimusmedica.com
A Mitogen is a small molecule made of amino acids that signal a cell to divide and duplicate.
This process, called mitosis, is fundamental to all types of life. When signaled by a mitogen …
This process, called mitosis, is fundamental to all types of life. When signaled by a mitogen …