Fundamentals of ion mobility spectrometry
Highlights•CCS distributions and shifts contain valuable information about
analytes.•Compound-dependent effects of gas, field and temperature explain calibration …
analytes.•Compound-dependent effects of gas, field and temperature explain calibration …
Mass spectrometry of nucleic acid noncovalent complexes
Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …
Addressing a common misconception: ammonium acetate as neutral pH “buffer” for native electrospray mass spectrometry
L Konermann - Journal of the American Society for Mass …, 2017 - ACS Publications
Native ESI-MS involves the transfer of intact proteins and biomolecular complexes from
solution into the gas phase. One potential pitfall is the occurrence of pH-induced changes …
solution into the gas phase. One potential pitfall is the occurrence of pH-induced changes …
Adding a new separation dimension to MS and LC–MS: what is the utility of ion mobility spectrometry?
Ion mobility spectrometry is an analytical technique known for more than 100 years, which
entails separating ions in the gas phase based on their size, shape, and charge. While ion …
entails separating ions in the gas phase based on their size, shape, and charge. While ion …
Charging and supercharging of proteins for mass spectrometry: recent insights into the mechanisms of electrospray ionization
Electrospray ionization (ESI) is an essential technique for transferring proteins from solution
into the gas phase for mass spectrometry and ion mobility spectrometry. The mechanisms …
into the gas phase for mass spectrometry and ion mobility spectrometry. The mechanisms …
Gas phase stability of protein ions in a cyclic ion mobility spectrometry traveling wave device
Ion mobility mass spectrometry (IM-MS) allows separation of native protein ions into
“conformational families”. Increasing the IM resolving power should allow finer structural …
“conformational families”. Increasing the IM resolving power should allow finer structural …
Map** the gaps in chemical analysis for the characterisation of aptamer-target interactions
Aptamers are promising biorecognition elements with a wide applicability from therapeutics
to biosensing. However, to successfully use these biomolecules, a complete …
to biosensing. However, to successfully use these biomolecules, a complete …
Collision-induced unfolding reveals disease-associated stability shifts in mitochondrial transfer ribonucleic acids
AG Anders, ED Tidwell, VV Gadkari… - Journal of the …, 2024 - ACS Publications
Ribonucleic acids (RNAs) remain challenging targets for structural biology, creating barriers
to understanding their vast functions in cellular biology and fully realizing their applications …
to understanding their vast functions in cellular biology and fully realizing their applications …
Ion mobility mass spectrometry uncovers the impact of the patterning of oppositely charged residues on the conformational distributions of intrinsically disordered …
The global dimensions and amplitudes of conformational fluctuations of intrinsically
disordered proteins are governed, in part, by the linear segregation versus clustering of …
disordered proteins are governed, in part, by the linear segregation versus clustering of …
Investigation of charge-state-dependent compaction of protein ions with native ion mobility–mass spectrometry and theory
The precise relationship between native gas-phase protein ion structure, charge,
desolvation, and activation remains elusive. Much evidence supports the Charge Residue …
desolvation, and activation remains elusive. Much evidence supports the Charge Residue …