The principal role of prolactin in mammals is the regulation of lactation. Prolactin is a
hormone that is mainly synthesized and secreted by lactotroph cells in the anterior pituitary …

The concept that different systems control episodic and surge secretion of gonadotropin‐
releasing hormone (GnRH) was well established by the time that GnRH was identified and …

Procreation is essential for survival of species. Not surprisingly, complex neuronal networks
have evolved to mediate the diverse internal and external environmental inputs that regulate …

In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified
in the mammalian hypothalamus, a plethora of new research has emerged adding insights …

Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic–pituitary–
gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in …

A fundamental principle in reproductive neuroendocrinology is sex steroid feedback: steroid
hormones secreted by the gonads circulate back to the brain to regulate the neural circuits …

Neuropeptides modulate neural circuits controlling adaptive animal behaviors and
physiological processes, such as feeding/metabolism, reproductive behaviors, circadian …

Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy)
neurons in the arcuate nucleus play a key role in GnRH pulse generation, with kisspeptin …

Hyperprolactinemia is the most common cause of hypogonadotropic anovulation and is one
of the leading causes of infertility in women aged 25–34. Hyperprolactinemia has been …

Ovarian control of gonadotrophin secretion is normally achieved via the feedback
mechanisms mediated by oestradiol and progesterone. Evidence has been provided that …