Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …

Background Gray matter volume (GMV) alterations in several emotion-related brain areas
are implicated in mood disorders, but findings have been inconsistent in adolescents with …

Positron emission tomography (PET) imaging with radiotracers that target translocator
protein 18 kDa (TSPO) has become a popular approach to assess putative …

The human gut microbiome plays an important role in the basic neurodevelopmental
processes of the central nervous system and has been implicated in several …

BACKGROUND: Previous studies have shown that frontostriatal networks, especially those
involving dorsolateral prefrontal cortex (DLPFC) and ventrolateral prefrontal cortex (VLPFC) …

Background: Magnetic resonance imaging studies have provided evidence of structural
modifications in cortical-limbic regions in major depressive disorder. To date, however, few …

A causal relationship between immune dysregulation and schizophrenia has been
supported by genome-wide association studies and epidemiological evidence. It remains …

Background Studies in adults with major depressive disorder (MDD) have implicated
dysregulation of frontal-limbic circuits in the symptomology of this disorder. We hypothesized …

Background Somatic symptoms are common among patients with major depressive disorder
(MDD), and are known to negatively impact the course and severity of the disease. Although …

Objective: Despite viral suppression, HIV-associated cognitive impairment persists and may
be partially due to persistent immune signalling by cells of the myeloid-lineage. Here, we …