Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration.
Many neurodegenerative diseases are age-related, including two of the most common …

The mouse brain is the most extensively studied brain of all species. We performed an
exhaustive review of the literature to establish our current state of knowledge on cell …

Microglia are the predominant immune response cells and professional phagocytes of the
central nervous system (CNS) that have been shown to be important for brain development …

The biological olfactory system is the sensory system responsible for the detection of the
chemical composition of the environment. Several attempts to mimic biological olfactory …

Like other sensory systems, olfactory function deteriorates with age. Epidemiological studies
have revealed that the incidence of olfactory dysfunction increases at the age of 60 and …

Loss of function of the gene SCN9A, encoding the voltage-gated sodium channel Nav1. 7,
causes a congenital inability to experience pain in humans. Here we show that Nav1. 7 is …

The prevalence of obesity in older people is the leading cause of metabolic syndromes.
Central neurons serving as homeostatic sensors for body-weight control include …

Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal
and molecular processes. Technological innovations now allow for parallel investigation of …

Population aging is accelerating rapidly worldwide, from 461 million people older than 65
years in 2004 to an estimated 2 billion people by 2050, leading to critical implications for the …

'Dying back'axon degeneration is a prominent feature of many age‐related
neurodegenerative disorders and is widespread in normal ageing. Although the …