Human pathogens that are transmitted by insects are a global problem, particularly those
vectored by mosquitoes; for example, malaria parasites transmitted by Anopheles species …

This article presents an overview of paratransgenesis as a strategy to control pathogen
transmission by insect vectors. It first briefly summarises some of the disease-causing …

The insect gut microbiota plays crucial roles in modulating the interactions between the host
and intestinal pathogens. Unlike viruses, bacteria, and parasites, which need to be ingested …

The huge burden of malaria in develo** countries urgently demands the development of
novel approaches to fight this deadly disease. Although engineered symbiotic bacteria have …

Mosquitoes are hematophagous vectors that can acquire human viruses in their intestinal
tract. Here, we define a mosquito gut commensal bacterium that promotes permissiveness to …

The importance of the microbiome to human health is increasingly recognized and has
become a major focus of recent research. However, much of the work has focused on a few …

The mosquito midgut stages of malaria parasites are crucial for establishing an infection in
the insect vector and to thus ensure further spread of the pathogen. Parasite development in …

Mosquito-transmitted diseases account for about 500 000 deaths every year. Blocking these
pathogens in the mosquito vector before they are transmitted to humans is an effective …

Nearly one million people are killed every year by the malaria parasite Plasmodium.
Although the disease-causing forms of the parasite exist only in the human blood …

The malaria development in the mosquito midgut is a complex process that results in
considerable parasite losses. The mosquito gut microbiota influences the outcome of …