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Deep learning in phosphoproteomics: methods and application in cancer drug discovery
Protein phosphorylation is a key post-translational modification (PTM) that is a central
regulatory mechanism of many cellular signaling pathways. Several protein kinases and …
regulatory mechanism of many cellular signaling pathways. Several protein kinases and …
Nuclear migration in budding yeasts: position before division
Positioning the nucleus to a specific cellular location is a prerequisite for high-fidelity
transmission of the genetic material to daughter cells. The cellular location of the nucleus …
transmission of the genetic material to daughter cells. The cellular location of the nucleus …
[HTML][HTML] A BAR homology domain containing protein, EhABP is the novel interactor of EhAK7, an aurora kinase homolog in E. histolytica
Biomolecular interactions among proteins are fundamental for all cellular functions. The
chromosome segregation proteins are the key regulators of inherent functions in the living …
chromosome segregation proteins are the key regulators of inherent functions in the living …
A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans
P Jaitly, M Legrand, A Das, T Patel, M Chauvel… - Nature …, 2022 - nature.com
Chromosomal instability caused by cell division errors is associated with antifungal drug
resistance in fungal pathogens. Here, we identify potential mechanisms underlying such …
resistance in fungal pathogens. Here, we identify potential mechanisms underlying such …
Shugoshin ensures maintenance of the spindle assembly checkpoint response and efficient spindle disassembly
Shugoshin proteins are evolutionarily conserved across eukaryotes, with some species‐
specific cellular functions, ensuring the fidelity of chromosome segregation. They act as …
specific cellular functions, ensuring the fidelity of chromosome segregation. They act as …
Evidence of 14-3-3 proteins contributing to kinetochore integrity and chromosome congression during mitosis
GK Anbalagan, P Agarwal… - Journal of Cell …, 2024 - journals.biologists.com
ABSTRACT The 14-3-3 family of proteins are conserved across eukaryotes and serve
myriad important regulatory functions in the cell. Homo-and hetero-dimers of these proteins …
myriad important regulatory functions in the cell. Homo-and hetero-dimers of these proteins …
[PDF][PDF] Current Research in Biotechnology
Biomolecular interactions among proteins are fundamental for all cellular functions. The
chromosome segregation proteins are the key regulators of inherent functions in the living …
chromosome segregation proteins are the key regulators of inherent functions in the living …
Functional plasticity in chromosome–microtubule coupling on the evolutionary time scale
SR Sankaranarayanan, SD Polisetty… - Life Science …, 2023 - life-science-alliance.org
The Dam1 complex is essential for mitotic progression across evolutionarily divergent fungi.
Upon analyzing amino acid (aa) sequences of Dad2, a Dam1 complex subunit, we identified …
Upon analyzing amino acid (aa) sequences of Dad2, a Dam1 complex subunit, we identified …
Loss of the SAC Components SldA Kinase or SldB or In Vitro Adaptation to Triazole Produces Aneuploidy Associated With Triazole Heteroresistance in Aspergillus …
AV Nywening - 2024 - search.proquest.com
The opportunistic pathogen Aspergillus fumigatus represents the chief causative agent of
human and animal invasive filamentous fungal infections. Triazoles, the primary therapeutic …
human and animal invasive filamentous fungal infections. Triazoles, the primary therapeutic …
DNA replication initiator proteins facilitate CENPA loading on early replicating compact chromatin
L Sreekumar, P Jaitly, Y Chen, BC Thimmappa… - bioRxiv, 2018 - biorxiv.org
The process of centromere formation enables the cell to conserve established genetic and
epigenetic information from the previous cell cycle and reuse it for future episodes of …
epigenetic information from the previous cell cycle and reuse it for future episodes of …