Deep learning in phosphoproteomics: methods and application in cancer drug discovery

N Varshney, AK Mishra - Proteomes, 2023 - mdpi.com
Protein phosphorylation is a key post-translational modification (PTM) that is a central
regulatory mechanism of many cellular signaling pathways. Several protein kinases and …

Nuclear migration in budding yeasts: position before division

N Varshney, K Sanyal - Current genetics, 2019 - Springer
Positioning the nucleus to a specific cellular location is a prerequisite for high-fidelity
transmission of the genetic material to daughter cells. The cellular location of the nucleus …

[HTML][HTML] A BAR homology domain containing protein, EhABP is the novel interactor of EhAK7, an aurora kinase homolog in E. histolytica

R Ghosh, P Biswas, A Chakraborty, S Pal, M Das… - Current Research in …, 2024 - Elsevier
Biomolecular interactions among proteins are fundamental for all cellular functions. The
chromosome segregation proteins are the key regulators of inherent functions in the living …

A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans

P Jaitly, M Legrand, A Das, T Patel, M Chauvel… - Nature …, 2022 - nature.com
Chromosomal instability caused by cell division errors is associated with antifungal drug
resistance in fungal pathogens. Here, we identify potential mechanisms underlying such …

Shugoshin ensures maintenance of the spindle assembly checkpoint response and efficient spindle disassembly

A Sane, S Sridhar, K Sanyal… - Molecular …, 2021 - Wiley Online Library
Shugoshin proteins are evolutionarily conserved across eukaryotes, with some species‐
specific cellular functions, ensuring the fidelity of chromosome segregation. They act as …

Evidence of 14-3-3 proteins contributing to kinetochore integrity and chromosome congression during mitosis

GK Anbalagan, P Agarwal… - Journal of Cell …, 2024 - journals.biologists.com
ABSTRACT The 14-3-3 family of proteins are conserved across eukaryotes and serve
myriad important regulatory functions in the cell. Homo-and hetero-dimers of these proteins …

[PDF][PDF] Current Research in Biotechnology

R Ghosh, P Biswas, A Chakraborty, S Pal… - Current Research in …, 2024 - academia.edu
Biomolecular interactions among proteins are fundamental for all cellular functions. The
chromosome segregation proteins are the key regulators of inherent functions in the living …

Functional plasticity in chromosome–microtubule coupling on the evolutionary time scale

SR Sankaranarayanan, SD Polisetty… - Life Science …, 2023 - life-science-alliance.org
The Dam1 complex is essential for mitotic progression across evolutionarily divergent fungi.
Upon analyzing amino acid (aa) sequences of Dad2, a Dam1 complex subunit, we identified …

Loss of the SAC Components SldA Kinase or SldB or In Vitro Adaptation to Triazole Produces Aneuploidy Associated With Triazole Heteroresistance in Aspergillus …

AV Nywening - 2024 - search.proquest.com
The opportunistic pathogen Aspergillus fumigatus represents the chief causative agent of
human and animal invasive filamentous fungal infections. Triazoles, the primary therapeutic …

DNA replication initiator proteins facilitate CENPA loading on early replicating compact chromatin

L Sreekumar, P Jaitly, Y Chen, BC Thimmappa… - bioRxiv, 2018 - biorxiv.org
The process of centromere formation enables the cell to conserve established genetic and
epigenetic information from the previous cell cycle and reuse it for future episodes of …