Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training

B Egan, AP Sharples - Physiological Reviews, 2023 - journals.physiology.org
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Integrating biomaterials and food biopolymers for cultured meat production

S Ng, M Kurisawa - Acta Biomaterialia, 2021 - Elsevier
Cultured meat has recently achieved mainstream prominence due to the emergence of
societal and industrial interest. In contrast to animal-based production of traditional meat, the …

DNA methylation across the genome in aged human skeletal muscle tissue and muscle-derived cells: the role of HOX genes and physical activity

DC Turner, PP Gorski, MF Maasar, RA Seaborne… - Scientific Reports, 2020 - nature.com
Skeletal muscle tissue demonstrates global hypermethylation with age. However,
methylome changes across the time-course of differentiation in aged human muscle derived …

UBR5 is a novel E3 ubiquitin ligase involved in skeletal muscle hypertrophy and recovery from atrophy

RA Seaborne, DC Hughes, DC Turner… - The Journal of …, 2019 - Wiley Online Library
Key points We have recently identified that a HECT domain E3 ubiquitin ligase, named
UBR5, is altered epigenetically (via DNA methylation) after human skeletal muscle …

Compact and tunable stretch bioreactor advancing tissue engineering implementation. Application to engineered cardiac constructs

G Putame, S Gabetti, D Carbonaro, F Di Meglio… - Medical Engineering & …, 2020 - Elsevier
Physical stimuli are crucial for the structural and functional maturation of tissues both in vivo
and in vitro. In tissue engineering applications, bioreactors have become fundamental and …

Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo

DC Turner, PP Gorski, RA Seaborne… - Journal of Cellular …, 2021 - Wiley Online Library
Understanding the role of mechanical loading and exercise in skeletal muscle (SkM) is
paramount for delineating the molecular mechanisms that govern changes in muscle mass …

Translating In Vitro Models of Exercise in Human Muscle Cells: A Mitocentric View

RX Yeo, J Noone, LM Sparks - Exercise and Sport Sciences …, 2024 - journals.lww.com
Skeletal muscle (SkM) is a major site of training-induced changes in substrate metabolism
through increased adenosine triphosphate turnover and mitochondrial oxidative capacity …

Skeletal Muscle Satellite Cell Physiology and Function: Complimentary In Vitro and In Vivo Models and Methods

M Viggars, A Nolan, A Sharples, C Stewart - … Assessments of Form and …, 2023 - Springer
Skeletal muscle is a highly adaptable tissue, displaying features of hypertrophy (growth) and
atrophy (loss), as a result of both internal and external stimuli. The mechanisms …

Integration of clinical perspective into biomimetic bioreactor design for orthopedics

V Drapal, JM Gamble, JL Robinson… - … Research Part B …, 2022 - Wiley Online Library
The challenges to accommodate multiple tissue formation metrics in conventional
bioreactors have resulted in an increased interest to explore novel bioreactor designs …

Does skeletal muscle have a memory of testosterone?

SF Christiansen - 2024 - nih.brage.unit.no
Recent evidence has shown that skeletal muscle tissue exhibits a memory of a range of
stimuli, enhancing the response to the stimuli if it has been previously encountered. Some …