The anti-inflammatory and immunological properties of SGLT-2 inhibitors
Background Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) are antidiabetic oral drugs
that act on proximal renal tubules promoting renal glucose excretion. Although SGLT-2i …
that act on proximal renal tubules promoting renal glucose excretion. Although SGLT-2i …
Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy
X Yan, Y **e, H Liu, M Huang, Z Yang, D An… - Diabetology & Metabolic …, 2023 - Springer
Diabetic cardiomyopathy (DC) is a serious heart disease caused by diabetes. It is unrelated
to hypertension and coronary artery disease and can lead to heart insufficiency, heart failure …
to hypertension and coronary artery disease and can lead to heart insufficiency, heart failure …
Novel thiazolidin-4-one benzenesulfonamide hybrids as PPARγ agonists: Design, synthesis and in vivo anti-diabetic evaluation
IH Ali, RM Hassan, AM El Kerdawy… - European Journal of …, 2024 - Elsevier
In the current study, two series of novel thiazolidin-4-one benzenesulfonamide arylidene
hybrids 9a-l and 10a-f were designed, synthesized and tested in vitro for their PPARɣ …
hybrids 9a-l and 10a-f were designed, synthesized and tested in vitro for their PPARɣ …
Oxidative stress management in cardiorenal diseases: focus on novel antidiabetic agents, finerenone, and melatonin
P Theofilis, A Vordoni, RG Kalaitzidis - Life, 2022 - mdpi.com
Oxidative stress is characterized by excessive production of reactive oxygen species
together with exhausted antioxidant defenses. This constitutes a main pathophysiologic …
together with exhausted antioxidant defenses. This constitutes a main pathophysiologic …
[HTML][HTML] New insights into the molecular mechanisms of SGLT2 inhibitors on ventricular remodeling
Y Chen, D Peng - International Immunopharmacology, 2023 - Elsevier
Ventricular remodeling is a pathological process of ventricular response to continuous
stimuli such as pressure overload, ischemia or ischemia–reperfusion, which can lead to the …
stimuli such as pressure overload, ischemia or ischemia–reperfusion, which can lead to the …
Dapagliflozin attenuates cardiac remodeling and dysfunction in rats with β-adrenergic receptor overactivation through restoring calcium handling and suppressing …
T Liu, J Wu, S Shi, B Cui, F **ong… - Diabetes & Vascular …, 2023 - journals.sagepub.com
Background: Long-term β-adrenergic receptor (β-AR) activation can impair myocardial
structure and function. Dapagliflozin (DAPA) has been reported to improve clinical prognosis …
structure and function. Dapagliflozin (DAPA) has been reported to improve clinical prognosis …
Dapagliflozin protects methamphetamine-induced cardiomyopathy by alleviating mitochondrial damage and reducing cardiac function decline in a mouse model
S He, Y Yao, N Yang, Y Wang, D Liu, Z Cao… - Frontiers in …, 2022 - frontiersin.org
Background: Methamphetamine (METH)-induced cardiovascular toxicity has been attributed
to its destructive effect on mitochondrial function at least to some extent. Previous studies …
to its destructive effect on mitochondrial function at least to some extent. Previous studies …
PLIN5 Suppresses Lipotoxicity and Ferroptosis in Cardiomyocyte via Modulating PIR/NF-κB Axis
X Shen, J Zhang, Z Zhou, R Yu - International Heart Journal, 2024 - jstage.jst.go.jp
Cardiomyocyte lipotoxicity and ferroptosis are the key to the development of diabetic
cardiomyopathy (DCM). Perilipin 5 (PLIN5) is perceived as a significant target of DCM. This …
cardiomyopathy (DCM). Perilipin 5 (PLIN5) is perceived as a significant target of DCM. This …
Effect of extracellular matrix stiffness on efficacy of Dapagliflozin for diabetic cardiomyopathy
T Zhu, Z Ye, J Song, J Zhang, Y Zhao, F Xu… - Cardiovascular …, 2024 - Springer
Background Extracellular matrix (ECM) stiffness is closely related to the progress of diabetic
cardiomyopathy (DCM) and the response of treatment of DCM to anti-diabetic drugs …
cardiomyopathy (DCM) and the response of treatment of DCM to anti-diabetic drugs …
Research advances in the anti-inflammatory effects of SGLT inhibitors in type 2 diabetes mellitus
R Zhang, Q **e, X Lu, R Fan, N Tong - Diabetology & Metabolic Syndrome, 2024 - Springer
Diabetes mellitus is one of the most significant global burden diseases. It is well established
that a chronic, systemic, low-grade inflammatory condition is strongly correlated with type 2 …
that a chronic, systemic, low-grade inflammatory condition is strongly correlated with type 2 …