Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

Non-alcoholic fatty liver disease: metabolic, genetic, epigenetic and environmental risk factors

O Juanola, S Martínez-López, R Francés… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver
disease in the Western world, probably due to the growing prevalence of obesity, metabolic …

A universal gut-microbiome-derived signature predicts cirrhosis

TG Oh, SM Kim, C Caussy, T Fu, J Guo, S Bassirian… - Cell metabolism, 2020 - cell.com
Dysregulation of the gut microbiome has been implicated in the progression of non-alcoholic
fatty liver disease (NAFLD) to advanced fibrosis and cirrhosis. To determine the diagnostic …

The gut–liver axis and the intersection with the microbiome

A Tripathi, J Debelius, DA Brenner, M Karin… - Nature reviews …, 2018 - nature.com
In the past decade, an exciting realization has been that diverse liver diseases—ranging
from nonalcoholic steatohepatitis, alcoholic steatohepatitis and cirrhosis to hepatocellular …

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Z Younossi, QM Anstee, M Marietti, T Hardy… - Nature reviews …, 2018 - nature.com
NAFLD is one of the most important causes of liver disease worldwide and will probably
emerge as the leading cause of end-stage liver disease in the coming decades, with the …

Gut microbiome-based metagenomic signature for non-invasive detection of advanced fibrosis in human nonalcoholic fatty liver disease

R Loomba, V Seguritan, W Li, T Long, N Klitgord… - Cell metabolism, 2017 - cell.com
The presence of advanced fibrosis in nonalcoholic fatty liver disease (NAFLD) is the most
important predictor of liver mortality. There are limited data on the diagnostic accuracy of gut …

Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology

M Eslam, J George - Nature reviews Gastroenterology & hepatology, 2020 - nature.com
Nonalcoholic fatty liver disease (NAFLD) affects around a quarter of the global population,
paralleling worldwide increases in obesity and metabolic syndrome. NAFLD arises in the …

Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver

P Dongiovanni, S Stender, A Pietrelli… - Journal of internal …, 2018 - Wiley Online Library
Abstract Background and Aims Nonalcoholic fatty liver disease is epidemiologically
associated with hepatic and metabolic disorders. The aim of this study was to examine …

[PDF][PDF] Optimal threshold of controlled attenuation parameter with MRI‐PDFF as the gold standard for the detection of hepatic steatosis

C Caussy, MH Alquiraish, P Nguyen… - …, 2018 - Wiley Online Library
The optimal threshold of controlled attenuation parameter (CAP) for the detection of hepatic
steatosis using both M and XL probe is unknown in nonalcoholic fatty liver disease (NAFLD) …

[HTML][HTML] Invited review liver fibrosis in NAFLD/NASH: From pathophysiology towards diagnostic and therapeutic strategies

M Parola, M Pinzani - Molecular Aspects of Medicine, 2024 - Elsevier
Liver fibrosis, as an excess deposition of extracellular matrix (ECM) components, results
from chronic liver injury as well as persistent activation of inflammatory response and of …