Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in
mammals and are responsible for the regulation of most physiological functions. Besides …

Background The human taste experience is the result of five basic taste qualities, namely
sweet, salty, bitter, sour and umami. Sweet, bitter, and umami are mediated by G protein …

Background The perception of taste is a prime example of complex signal transduction at the
subcellular level, involving an intricate network of molecular machinery, which can be …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

When a measure becomes a target, it ceases to be a good measure. For example, when
standardized test scores in education become targets, teachers may start “teaching to the …

Rising living standards heighten the demand for healthier sugar-reduced foods. This study
used Headspace Solid-Phase Microextraction (HS-SPME) and Gas Chromatography …

Knowing the mechanism of action of sweet taste receptors is important for the design of new,
healthy sweeteners. However, little is known about the structures and recognition …

Taste sensation enables humans to make nutritionally important decisions such as food
preference and consumption. It functions as deterministic factors for unpropitious eating …

Molecular modeling approaches are an indispensable part of the drug design process. They
not only support the process of searching for new ligands of a given receptor, but they also …

Umami substances can increase the overall taste of food and bring pleasure to people.
However, it is still challenging to identify the umami molecules through virtual screening due …