Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits

KJ Ressler, S Berretta, VY Bolshakov… - Nature Reviews …, 2022 - nature.com
Post-traumatic stress disorder (PTSD) is a maladaptive and debilitating psychiatric disorder,
characterized by re-experiencing, avoidance, negative emotions and thoughts, and …

Why is depression more common among women than among men?

C Kuehner - The Lancet Psychiatry, 2017 - thelancet.com
Women are about twice as likely as are men to develop depression during their lifetime. This
Series paper summarises evidence regarding the epidemiology on gender differences in …

Stress and obesity: are there more susceptible individuals?

ES Van der Valk, M Savas, EFC van Rossum - Current obesity reports, 2018 - Springer
Abstract Purpose of Review Stress has long been suspected to be interrelated to
(abdominal) obesity. However, interindividual differences in this complex relationship exist …

Comorbidity between post-traumatic stress disorder and major depressive disorder: alternative explanations and treatment considerations

JD Flory, R Yehuda - Dialogues in clinical neuroscience, 2015 - Taylor & Francis
Approximately half of people with post-traumatic stress disorder (PTSD) also suffer from
Major Depressive Disorder (MDD). The current paper examines evidence for two …

Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications

AS Zannas, T Wiechmann, NC Gassen… - …, 2016 - nature.com
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for develo** individualized …

The genetics of stress-related disorders: PTSD, depression, and anxiety disorders

JW Smoller - Neuropsychopharmacology, 2016 - nature.com
Research into the causes of psychopathology has largely focused on two broad etiologic
factors: genetic vulnerability and environmental stressors. An important role for …

Stress and fear extinction

S Maren, A Holmes - Neuropsychopharmacology, 2016 - nature.com
Stress has a critical role in the development and expression of many psychiatric disorders,
and is a defining feature of posttraumatic stress disorder (PTSD). Stress also limits the …

[HTML][HTML] High anxiety trait: a vulnerable phenotype for stress-induced depression

M Weger, C Sandi - Neuroscience & Biobehavioral Reviews, 2018 - Elsevier
A great deal of research aims to identify risk factors related to individual vulnerability to
develop stress-induced psychopathologies. Here, we summarize evidence that point at …

Candidate gene–environment interaction research: Reflections and recommendations

DM Dick, A Agrawal, MC Keller… - Perspectives on …, 2015 - journals.sagepub.com
Studying how genetic predispositions come together with environmental factors to contribute
to complex behavioral outcomes has great potential for advancing the understanding of the …

[HTML][HTML] Child maltreatment and the development of substance use and disorder

D Cicchetti, ED Handley - Neurobiology of stress, 2019 - Elsevier
Children who experience maltreatment are at well-documented risk for the development of
problematic substance use and disorder in adolescence and beyond. This review applies a …