T-cell quality in memory and protection: implications for vaccine design
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter
flow cytometry has allowed a simultaneous assessment of the phenotype and multiple …
flow cytometry has allowed a simultaneous assessment of the phenotype and multiple …
Seventeen-colour flow cytometry: unravelling the immune system
SP Perfetto, PK Chattopadhyay… - Nature Reviews …, 2004 - nature.com
The increasing need for polychromatic approaches to flow cytometry, coupled with rapid
technological advances, has pushed the frontiers of flow cytometry beyond 12-colour …
technological advances, has pushed the frontiers of flow cytometry beyond 12-colour …
Lineage relationship and protective immunity of memory CD8 T cell subsets
Memory CD8 T cells can be divided into two subsets, central (TCM) and effector (TEM), but
their lineage relationships and their ability to persist and confer protective immunity are not …
their lineage relationships and their ability to persist and confer protective immunity are not …
Memory CD8 T-cell differentiation during viral infection
Memory CD8 T cells are an important component of protective immunity against viral
infections, and understanding their development will aid in the design of optimal vaccines …
infections, and understanding their development will aid in the design of optimal vaccines …
[HTML][HTML] Similarities and differences in CD4+ and CD8+ effector and memory T cell generation
RA Seder, R Ahmed - Nature immunology, 2003 - nature.com
Abstract Naive CD4+ and CD8+ T cells undergo unique developmental programs after
activation, resulting in the generation of effector and long-lived memory T cells. Recent …
activation, resulting in the generation of effector and long-lived memory T cells. Recent …
Chemokines: multiple levels of leukocyte migration control☆
B Moser, M Wolf, A Walz, P Loetscher - Trends in immunology, 2004 - cell.com
The surge in interest in chemokines is explained by the recognition that numerous aspects
of immunity are intimately related to leukocyte traffic. Chemokines are leukocyte attractants …
of immunity are intimately related to leukocyte traffic. Chemokines are leukocyte attractants …
Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection
Heterogeneity is a hallmark of the adaptive immune system. This is most evident in the
enormous diversity of B and T cell antigen receptors. There is also heterogeneity within …
enormous diversity of B and T cell antigen receptors. There is also heterogeneity within …
CD8+ T‐cell memory in tumor immunology and immunotherapy
The cellular and molecular mechanisms underlying the formation of distinct central, effector,
and exhausted CD8+ T‐cell memory subsets were first described in the setting of acute and …
and exhausted CD8+ T‐cell memory subsets were first described in the setting of acute and …
CCL19 and CCR7 expression, signaling pathways, and adjuvant functions in viral infection and prevention
Chemokine (C–C motif) ligand 19 (CCL19) is a critical regulator of the induction of T cell
activation, immune tolerance, and inflammatory responses during continuous immune …
activation, immune tolerance, and inflammatory responses during continuous immune …
Progressive differentiation and selection of the fittest in the immune response
T cells are stimulated by stochastic exposure to antigen-presenting cells and cytokines. We
review evidence that the level of signal that is accumulated determines progression through …
review evidence that the level of signal that is accumulated determines progression through …