Tremendous advances in our understanding of the thrombotic microangiopathies (TMAs)
have revealed distinct disease mechanisms within this heterogeneous group of diseases. As …

Hemolytic uremic syndrome (HUS) is a triad of microangiopathic hemolytic anemia,
thrombocytopenia, and acute renal failure. The atypical form of HUS is a disease …

The serum protein complement factor H (FH) ensures downregulation of the complement
alternative pathway, a branch of innate immunity, upon interaction with specific glycans on …

Factor H related proteins comprise a group of five plasma proteins: CFHR1, CFHR2,
CFHR3, CFHR4 and CFHR5, and each member of this group binds to the central …

Complement factor H-related proteins (FHRs) are strongly associated with different diseases
involving complement dysregulation, which suggests a major role for these proteins …

The complement system, while being an essential and very efficient effector component of
innate immunity, may cause damage to the host and result in various inflammatory …

Complement factor H (CFH) regulates complement activation in host tissues through its
recognition of polyanions, which mediate CFH binding to host cell surfaces and extracellular …

Factor H (FH) is a soluble regulator of the proteolytic cascade at the core of the evolutionarily
ancient vertebrate complement system. Although FH consists of a single chain of similar …

The complement alternative pathway is a powerful arm of the innate immune system that
enhances diverse inflammatory responses in the human host. Key to the effects of the …

This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …