The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs)
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …

Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …

SMARCA4/BRG1 encodes for one of two mutually exclusive ATPases present in mammalian
SWI/SNF chromatin remodeling complexes and is frequently mutated in human lung …

Background Bone or brain metastases may develop in 20–40% of individuals with late‐
stage non‐small‐cell lung cancer (NSCLC), resulting in a median overall survival of only 4 …

Ferroptosis, an iron-dependent cell death process, is a potential therapeutic strategy for
Lung squamous cell carcinoma (LUSC). Resveratrol (RES) is an anti-tumor polyphenol …

Background Lung cancer (LC) causes more deaths worldwide than any other cancer type.
Despite advances in therapeutic strategies, the fatality rate of LC cases remains high (95%) …

Reprogramming of the tumor microenvironment (TME) plays a critical role in gastric cancer
(GC) progression and metastasis. However, the multidimensional features between primary …

Background Lung squamous cell carcinoma (LUSC) is associated with high mortality and
has limited therapeutic treatment options. Plasminogen activator urokinase (PLAU) plays …

Purpose Although definitive chemoradiation therapy (dCRT) remains the most effective
treatment modality in limited stage small cell lung cancer (SCLC), some patients progress …

Lung cancer is one of the deadliest malignancies worldwide, with distant metastasis being a
major cause of death. However, the specific mechanisms of lung cancer metastasis remain …