Until recently, the signaling events elicited in vascular smooth muscle cells by angiotensin II
(Ang II) were considered to be rapid, short-lived, and divided into separate linear pathways …

L-arginine analogues are widely used inhibitors of nitric oxide synthase (NOS) activity both
in vitro and in vivo, with N ω-nitro-L-arginine methyl ester (L-NAME) being at the head. On …

The incremental elastic modulus of the common carotid and radial arteries is increased in
patients with end-stage renal disease (ESRD), independently of blood pressure, wall stress …

The endothelins (ET) are a family of contractile peptides made up of 21 amino acids. They
are synthesised from larger precursors and they are expressed in different tissues. ET-1 is …

Sodium plays an important role in the pathogenesis and therapy of hypertension, a major
risk factor for cardiovascular disease. This study investigated the involvement of endothelin …

Hypertension is one of the most prevalent and powerful contributors of cardiovascular
diseases. Malignant hypertension is a relatively rare but extremely severe form of …

The adaptive changes that occur in the left ventricle (LV) and vessels in response to
hypertension, namely, muscle hypertrophy/hyperplasia, endothelial dysfunction, and …

Because of the significant constitutive expression of NO synthases in the juxtaglomerular
apparatus, nitric oxide (NO) is considered as a likely modulator of renin secretion. In most …

Left ventricular hypertrophy (LVH) is the result of interaction between a chronic
hemodynamic overload and nonhemodynamic factors. There are several lines of evidence …

The thick ascending limb plays a key role in maintaining water and electrolyte balance. The
importance of this segment in regulating blood pressure is evidenced by the effect of loop …