High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …

N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …

High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with
the severity and mortality of sepsis. However, it is unclear whether lactate could promote …

Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin,
HMGB1 is now known to regulate diverse biological processes depending on its subcellular …

Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Multicellular animals detect pathogens via a set of receptors that recognize pathogen-
associated molecular patterns (PAMPs). However, pathogens are not the only causative …

Pathogen‐associated molecular pattern molecules (PAMP s) are derived from
microorganisms and recognized by pattern recognition receptor (PRR)‐bearing cells of the …

High-mobility group box 1 protein (HMGB1), which previously was thought to function only
as a nuclear factor that enhances transcription, was recently discovered to be a crucial …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …