Background Elucidation of mechanisms regulating bone metastasis has progressed
significantly in recent years and this has translated to many new therapeutic options for …

The skeleton is a common destination for many cancer metastases including breast and
prostate cancer. There are many characteristics of bone that make it an ideal environment …

Compelling evidences suggest that increased production of osteoclastogenic cytokines by
activated T cells plays a relevant role in the bone loss induced by estrogen deficiency in the …

Selenoproteins containing selenium in the form of selenocysteine are critical for bone
remodeling. However, their underlying mechanism of action is not fully understood. Herein …

In the last years, new evidences of the relationship between immune system and bone have
been accumulated both in animal models and in humans affected by bone disease, such as …

Bone metastasis is associated with significant morbidity for cancer patients and results in a
reduced quality of life. The bone marrow is a fertile soil containing a complex composition of …

Purpose: Tooth extraction is a last resort treatment for resolving pathological complications
of dentition induced by infection and injury. Although the extraction wound generally heals …

Bone is the most common site of metastases from prostate cancer. The mechanism by which
prostate cancer cells metastasize to bone is not fully understood, but interactions between …

Objective To analyze cellular mechanisms of bone erosion in gout. Methods Peripheral
blood mononuclear cells (PBMCs) and synovial fluid mononuclear cells (SFMCs) from …

Simvastatin, an inhibitor of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase, is a
cholesterol‐lowering drug that may play a role in bone metabolism through a mechanism …