Innovations in genomics and big data analytics for personalized medicine and health care: A review
Big data in health care is a fast-growing field and a new paradigm that is transforming case-
based studies to large-scale, data-driven research. As big data is dependent on the …
based studies to large-scale, data-driven research. As big data is dependent on the …
Computational models for clinical applications in personalized medicine—guidelines and recommendations for data integration and model validation
CB Collin, T Gebhardt, M Golebiewski… - Journal of personalized …, 2022 - mdpi.com
The future development of personalized medicine depends on a vast exchange of data from
different sources, as well as harmonized integrative analysis of large-scale clinical health …
different sources, as well as harmonized integrative analysis of large-scale clinical health …
Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility
FT Musuamba, I Skottheim Rusten… - CPT …, 2021 - Wiley Online Library
The value of in silico methods in drug development and evaluation has been demonstrated
repeatedly and convincingly. While their benefits are now unanimously recognized …
repeatedly and convincingly. While their benefits are now unanimously recognized …
Personalized medicine for patients with COPD: where are we?
FME Franssen, P Alter, N Bar… - … journal of chronic …, 2019 - Taylor & Francis
Chronic airflow limitation is the common denominator of patients with chronic obstructive
pulmonary disease (COPD). However, it is not possible to predict morbidity and mortality of …
pulmonary disease (COPD). However, it is not possible to predict morbidity and mortality of …
Deep learning in systems medicine
H Wang, E Pujos-Guillot, B Comte… - Briefings in …, 2021 - academic.oup.com
Abstract Systems medicine (SM) has emerged as a powerful tool for studying the human
body at the systems level with the aim of improving our understanding, prevention and …
body at the systems level with the aim of improving our understanding, prevention and …
Leveraging transcriptomics for precision diagnosis: Lessons learned from cancer and sepsis
M Tsakiroglou, A Evans, M Pirmohamed - Frontiers in Genetics, 2023 - frontiersin.org
Diagnostics require precision and predictive ability to be clinically useful. Integration of multi-
omic with clinical data is crucial to our understanding of disease pathogenesis and …
omic with clinical data is crucial to our understanding of disease pathogenesis and …
Multi-omics profiling of the tumor microenvironment: paving the way to precision immuno-oncology
F Finotello, F Eduati - Frontiers in Oncology, 2018 - frontiersin.org
The tumor microenvironment (TME) is a multifaceted ecosystem characterized by profound
cellular heterogeneity, dynamicity, and complex intercellular cross-talk. The striking …
cellular heterogeneity, dynamicity, and complex intercellular cross-talk. The striking …
Oxidative stress in type 2 diabetes: The case for future pediatric redoxomics studies
Considerable evidence supports the role of oxidative stress in adult type 2 diabetes (T2D).
Due to increasing rates of pediatric obesity, lack of physical activity, and consumption of …
Due to increasing rates of pediatric obesity, lack of physical activity, and consumption of …
Are all models wrong?
H Enderling, O Wolkenhauer - Computational and systems …, 2021 - pmc.ncbi.nlm.nih.gov
Mathematical modeling in cancer is enjoying a rapid expansion (Brady & Enderling, 2019).
For collegial discussion across disciplines, many-if not all of us-have used the aphorism that …
For collegial discussion across disciplines, many-if not all of us-have used the aphorism that …
Intercellular pathways of cancer treatment-related cardiotoxicity and their therapeutic implications: the paradigm of radiotherapy
Advances in cancer therapeutics have improved patient survival rates. However, cancer
survivors may suffer from adverse events either at the time of therapy or later in life …
survivors may suffer from adverse events either at the time of therapy or later in life …