The human immune system is made up of a huge variety of cell types each with unique
functions. Local networks of resident immune cells are poised to sense and protect against …

Evolutionary immunology has entered a new era. Classical studies, using just a handful of
model animal species, combined with clinical observations, provided an outline of how …

Human embryonic bone and joint formation is determined by coordinated differentiation of
progenitors in the nascent skeleton. The cell states, epigenetic processes and key regulatory …

Although aging clocks predicting the age of individual organisms have been extensively
studied, the age of individual cells remained largely unexplored. Most recently single-cell …

Cellular atlases are unlocking the mysteries of the human body Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

Developmental dynamics encompass both the specification of cell types and their spatial
organisation into multicellular niches. Here we harness the power of single-cell and spatial …

Recent technological advances have transformed our understanding of the human thymus.
Innovations such as high-resolution imaging, single-cell omics, and organoid cultures …

The thymus plays a pivotal role in generating a highly-diverse repertoire of T lymphocytes
while preventing autoimmunity. Thymus seeding progenitors (TSPs) are a heterogeneous …

Thymic mimetic cells are molecular hybrids between medullary-thymic-epithelial cells
(mTECs) and diverse peripheral cell types. They are involved in eliminating autoreactive T …

The thymus plays a central role in the development and education of T cells. Studying the
human thymus is notoriously challenging due to limited access to healthy sample tissue and …