Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances

W Wang, F Zhao, X Ma, G Perry, X Zhu - Molecular neurodegeneration, 2020 - Springer
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Redox-and non-redox-metal-induced formation of free radicals and their role in human disease

M Valko, K Jomova, CJ Rhodes, K Kuča… - Archives of toxicology, 2016 - Springer
Transition metal ions are key elements of various biological processes ranging from oxygen
formation to hypoxia sensing, and therefore, their homeostasis is maintained within strict …

[HTML][HTML] NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's …

MW Park, HW Cha, J Kim, JH Kim, H Yang, S Yoon… - Redox biology, 2021 - Elsevier
Oxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD).
Mitochondrial dysfunction is linked to oxidative stress and reactive oxygen species (ROS) in …

Mitochondrial dysfunction and oxidative stress in aging and cancer

AV Kudryavtseva, GS Krasnov, AA Dmitriev… - …, 2016 - pmc.ncbi.nlm.nih.gov
Aging and cancer are the most important issues to research. The population in the world is
growing older, and the incidence of cancer increases with age. There is no doubt about the …

Molecular mechanisms and genetics of oxidative stress in Alzheimer's disease

F Cioffi, RHI Adam, K Broersen - Journal of Alzheimer's …, 2019 - journals.sagepub.com
Alzheimer's disease is the most common neurodegenerative disorder that can cause
dementia in elderly over 60 years of age. One of the disease hallmarks is oxidative stress …

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

MH Yan, X Wang, X Zhu - Free Radical Biology and Medicine, 2013 - Elsevier
Alzheimer disease (AD) and Parkinson disease (PD) are the two most common age-related
neurodegenerative diseases characterized by prominent neurodegeneration in selective …

[HTML][HTML] 4-Hydroxynonenal (HNE) modified proteins in metabolic diseases

JP Castro, T Jung, T Grune, W Siems - Free Radical Biology and Medicine, 2017 - Elsevier
Hydroxynonenal (HNE) is one of the quantitatively most important products of lipid
peroxidation. Due to its high toxicity it is quickly metabolized, however, a small share of HNE …

[HTML][HTML] CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model …

G Ates, J Goldberg, A Currais, P Maher - Redox biology, 2020 - Elsevier
The oxidative degradation of lipids has been shown to be implicated in the progression of
several neurodegenerative diseases and modulating lipid peroxidation may be efficacious …

Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update

MA Bradley-Whitman, MA Lovell - Archives of toxicology, 2015 - Springer
Increasing evidence suggests that free radical-mediated oxidation of biological substrates is
a key feature of Alzheimer's disease (AD) pathogenesis. While it has long been established …

Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease

A Goyal, K Solanki, A Verma - Journal of Biochemical and …, 2024 - Wiley Online Library
Neurodegenerative disorders (NDs) are defined as the slow loss of a group of neurons that
are particularly sensitive. Due to the intricate pathophysiological processes underlying …