Vasculitis of the medium and large arteries, most often presenting as giant cell arteritis
(GCA), is an infrequent, but potentially fatal, type of immune-mediated vascular disease. The …

Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic
programs that enhance resistance to viral infection. Induction of an antiviral state at the cell …

RESULTS We investigated one sporadic case and the probands from five multiplex kindreds
with AD CMCD, by whole-exome sequencing. The annotated data were analyzed with …

Vitiligo is an autoimmune skin disease characterized by the targeted destruction of
melanocytes by T cells. Cytokine signaling between keratinocytes and T cells results in …

Innate immune cells, particularly macrophages and epithelial cells, play a key role in
multiple layers of immune responses. Alarmins and pro-inflammatory cytokines from the IL …

Inborn errors of the genes encoding two of the four human JAKs (JAK3 and TYK2) and three
of the six human STATs (STAT1, STAT3, and STAT5B) have been described. We review the …

Interleukin 17–producing helper T cells (TH17 cells) have a major role in protection against
infections and in mediating autoimmune diseases, yet the mechanisms involved are …

In 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped
into the so-called IL-10 family of cytokines based on their similarities with respect to the …

Psoriasis vulgaris, affecting the skin, is one of the most common organ-specific autoimmune
diseases in humans. Until recently, psoriasis was treated by agents or approaches …

Itch (or pruritus) was not previously recognized as a serious symptom of psoriasis. However,
approximately 60–90% of psoriatic patients with pruritus have stated that it deteriorates their …