New opportunities and perspectives on biosynthesis and bioactivities of secondary metabolites from Aloe vera

MV Ushasree, Q Jia, SG Do, EY Lee - Biotechnology Advances, 2024 - Elsevier
Historically, the genus Aloe has been an indispensable part of both traditional and modern
medicine. Decades of intensive research have unveiled the major bioactive secondary …

Insulin fibrillation: Strategies for inhibition

M Qafary, F Rashno, K Khajeh, M Khaledi… - Progress in Biophysics …, 2022 - Elsevier
Insulin and its homologous are the most utilized protein drugs due to their role in diabetic
patients' treatment. Insulin forms amyloid-like fibrils in vivo at the injection site. Therefore, the …

Antioxidant and alpha-glucosidase enzyme inhibitory properties of hydrolyzed protein and bioactive peptides of quinoa

S Abbasi, M Moslehishad, M Salami - International Journal of Biological …, 2022 - Elsevier
The quinoa protein is gaining global attraction due to high content of gluten-free protein. It is
a rich source of high-quality protein with all essential amino acids. The objective of this study …

[HTML][HTML] LC-MS characterization of bioactive metabolites from two Yemeni Aloe spp. with antioxidant and antidiabetic properties

TS Aldayel, MH Grace, MA Lila, MA Yahya… - Arabian Journal of …, 2020 - Elsevier
Abstract Two Yemeni Aloe (s) have been investigated; the resin from A. perry Baker (APR,
Socotran Aloe), and the gel from A. vera (AVG, Saber Yamaniis). LC-MS for APR identified …

Can Polyherbal Medicine be used for the Treatment of Diabetes?-A Review of Historical Classics, Research Evidence and Current Prevention Programs

S Brahma, AK Goyal, P Dhamodhar… - Current Diabetes …, 2024 - benthamdirect.com
Diabetes mellitus (DM), a chronic medical condition, has attained a global pandemic status
over the last few decades affecting millions of people. Despite a variety of synthetic drugs …

Inhibitory activities of GDX-365 on HMGB1-mediated septic responses

DH Baek, GO Kim, HJ Choi, MY Yun, DH Park… - Biotechnology and …, 2023 - Springer
GDX-365, is the main fraction of black ginseng comprising protopanaxatriol-type rare
ginsenosides (ginsenosides Rg3, Rk1, and Rg5). High mobility group box 1 (HMGB1) is …

Nutraceutical, therapeutic, and pharmaceutical potential of Aloe vera: A review

RK Upadhyay - International Journal of Green Pharmacy (IJGP), 2018 - greenpharmacy.info
The present review explains therapeutic and pharmaceutical potential of Aloe vera a well-
known plant grows in semi-arid climate of tropical and subtropical regions. This article …

Intermediate-aided allostery mechanism for α-glucosidase by Xanthene-11v as an inhibitor using residue interaction network analysis

Z Moosavi-Movahedi, N Salehi… - Journal of Molecular …, 2023 - Elsevier
Exploring allosteric inhibition and the discovery of new inhibitor binding sites are important
studies in protein regulation mechanisms and drug discovery. Structural and network-based …

[HTML][HTML] Aloe ferox leaf gel extracts attenuate redox imbalance in oxidative renal injury and stimulates glucose uptake, whilst inhibiting key enzymes linked to diabetes …

H Ismail, AI Mohamed, MS Islam - Scientific African, 2024 - Elsevier
The worldwide prevalence of diabetes and obesity is growing rapidly. Both metabolic
disorders are linked to chronic adverse complications, which include kidney dysfunctions …

Natural peptide anti-glycation effect in the presence of Aloe vera phenolic components on human serum albumin

AA Moosavi-Movahedi, F Ghamari, SM Ghaffari… - RSC Advances, 2015 - pubs.rsc.org
The Maillard reaction, non-enzymatic glycation after a complex series of reactions that
involve reducing-sugars and proteins, produces a large number of end-products that are …