Cancer immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the
treatment of advanced cancers. However, the tumor microenvironment (TME) functions as a …

Tumor cells constantly interact with their microenvironment, which comprises a variety of
immune cells together with endothelial cells and fibroblasts. The composition of the tumor …

Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …

Hypoxia, a hallmark of solid tumors, determines the selection of invasive and aggressive
malignant clones displaying resistance to radiotherapy, conventional chemotherapy or …

Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …

In the era of precision medicine, it has been increasingly recognized that individuals with a
certain disease are complex and different from each other. Due to the underestimation of the …

Induction of tumor vascular normalization is a crucial measure to enhance immunotherapy
efficacy. cGAS-STING pathway is vital for anti-tumor immunity, but its role in tumor …

Antiangiogenic agents, generally antibodies or tyrosine-kinase inhibitors that target the
VEGF–VEGFR pathway, are currently among the few combination partners clinically proven …

The efficacy of immunotherapy is limited by the paucity of T cells delivered and infiltrated into
the tumors through aberrant tumor vasculature. Here, we report that phosphoglycerate …

Background and Aims Activation of the antitumor immune response using programmed
death receptor‐1 (PD‐1) blockade showed benefit only in a fraction of patients with …