Engineering cellular metabolism
Metabolic engineering is the science of rewiring the metabolism of cells to enhance
production of native metabolites or to endow cells with the ability to produce new products …
production of native metabolites or to endow cells with the ability to produce new products …
ROS-mediated lipid peroxidation and RES-activated signaling
Nonenzymatic lipid oxidation is usually viewed as deleterious. But if this is the case, then
why does it occur so frequently in cells? Here we review the mechanisms of membrane …
why does it occur so frequently in cells? Here we review the mechanisms of membrane …
Mechanistic links between cellular trade-offs, gene expression, and growth
Intracellular processes rarely work in isolation but continually interact with the rest of the cell.
In microbes, for example, we now know that gene expression across the whole genome …
In microbes, for example, we now know that gene expression across the whole genome …
Quantitative proteomic analysis reveals a simple strategy of global resource allocation in bacteria
S Hui, JM Silverman, SS Chen, DW Erickson… - Molecular systems …, 2015 - embopress.org
A central aim of cell biology was to understand the strategy of gene expression in response
to the environment. Here, we study gene expression response to metabolic challenges in …
to the environment. Here, we study gene expression response to metabolic challenges in …
Shifts in growth strategies reflect tradeoffs in cellular economics
The growth rate‐dependent regulation of cell size, ribosomal content, and metabolic
efficiency follows a common pattern in unicellular organisms: with increasing growth rates …
efficiency follows a common pattern in unicellular organisms: with increasing growth rates …
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
Organisms are constantly exposed to a wide range of environmental changes, including
both short-term changes during their lifetime and longer-term changes across generations …
both short-term changes during their lifetime and longer-term changes across generations …
Effects of aneuploidy on cellular physiology and cell division in haploid yeast
Aneuploidy is a condition frequently found in tumor cells, but its effect on cellular physiology
is not known. We have characterized one aspect of aneuploidy: the gain of extra …
is not known. We have characterized one aspect of aneuploidy: the gain of extra …
Gene copy-number alterations: a cost-benefit analysis
YC Tang, A Amon - Cell, 2013 - cell.com
Changes in DNA copy number, whether confined to specific genes or affecting whole
chromosomes, have been identified as causes of diseases and developmental …
chromosomes, have been identified as causes of diseases and developmental …
Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism
Production of fuels and chemicals by industrial biotechnology requires efficient, safe and
flexible cell factory platforms that can be used for production of a wide range of compounds …
flexible cell factory platforms that can be used for production of a wide range of compounds …
Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast
We studied the relationship between growth rate and genome-wide gene expression, cell
cycle progression, and glucose metabolism in 36 steady-state continuous cultures limited by …
cycle progression, and glucose metabolism in 36 steady-state continuous cultures limited by …