1. More than 1300 coumarins have been identified from natural sources, especially green
plants. The pharmacological and biochemical properties and therapeutic applications of …

The metabolism, toxicity and results of tests for carcinogenicity have been reviewed with
respect to the safety for humans of coumarin present in foodstuffs and from fragrance use in …

The cytochromes P450 are a superfamily of hemoproteins that catalyze the metabolism of a
large number of xenobiotics and endobiotics. The type and amount (ie, the animal's …

Coumarin is an effective treatment for primary lymphoedema, as well as lymphoedema
related to breast cancer radiotherapy or surgery. However, its clinical use is limited in …

AS a family of structurally-related enzymes, cytochrome P450 (P450) monooxygenases
exhibit paradoxical characteristics: although collectively the enzymes display a broad range …

Liver cancer is a major cause of premature death in many areas of Africa and Asia and its
incidence is strongly correlated with exposure to aflatoxin B1 (AFB1). Because AFB1 …

Antibody against purified CYP2A1 recognizes two rat liver microsomal P450 enzymes,
CYP2A1 and CYP2A2, that catalyze the 7α-and 15α-hydroxylation of testosterone …

Coumarin (1, 2-benzopyrone) is a naturally occurring fragrant compound found in a variety
of plants and spices. Exposure to the general public is through the diet and from its use as a …

1. We have constructed a full-length human liver cytochrome P450IIA cDNA from a partial-
length clone by oligonucleotide-directed mutagenesis, and subcloned it into the monkey …

The cytochrome P450 superfamily of mixed-function oxygenases has been extensively
studied due to its many critical metabolic roles, and also because it is a fascinating example …