Since their establishment thirty years ago, THP-1 cells have become one of most widely
used cell lines to investigate the function and regulation of monocytes and macrophages in …

Inflammation is an important pathogenic factor of cardiovascular diseases. Inflammatory
processes induce the organism systemic changes that are sensed by the cells of innate …

Aims Migration of monocytes into the arterial wall contributes to arterial inflammation and
atherosclerosis progression. Since elevated low-density lipoprotein cholesterol (LDL-C) …

Background—Preventing atherosclerotic plaque destabilization and rupture is the most
reasonable therapeutic strategy for acute myocardial infarction. Therefore, we tested the …

Aims Monocyte-mediated inflammation is a major mechanism underlying myocardial
ischaemia–reperfusion (IR) injury and the healing process after acute myocardial infarction …

Myocardial ischemia-reperfusion (IR) injury limits the therapeutic effect of early reperfusion
therapy for acute myocardial infarction (AMI), in which the recruitment of inflammatory …

Influenza A virus is a significant cause of morbidity and mortality worldwide. Severe
influenza is recognized as a clinical syndrome, characterized by hyperinduction of …

Signaling by heptahelical G protein–coupled receptors (GPCR) regulates many vital body
functions. Consequently, dysfunction of GPCR signaling leads to pathologic states, and …

Background and Purpose—The pathophysiology of cerebral aneurysms (CAs) is linked to
chronic inflammation and degradation of extracellular matrix in vascular walls. Because …

While compelling evidence indicates beneficial effects of statins on inflammatory processes,
besides their cholesterol-lowering activities, the actions on angiogenesis are less clear-cut …