Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …
supports normal tissue turnover and can mount a regenerative response following acute …
Systems and synthetic microRNA biology: from biogenesis to disease pathogenesis
H Matsuyama, HI Suzuki - International journal of molecular sciences, 2019 - mdpi.com
MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …
Stem-cell aging and pathways to precancer evolution
Stem-Cell Aging and Pathways to Precancer Evolution | New England Journal of Medicine Skip
to main content The New England Journal of Medicine homepage Advanced Search SEARCH …
to main content The New England Journal of Medicine homepage Advanced Search SEARCH …
Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications
Drug resistance is a major hurdle in cancer treatment and a key cause of poor prognosis.
Epitranscriptomics and epiproteomics are crucial in cell proliferation, migration, invasion …
Epitranscriptomics and epiproteomics are crucial in cell proliferation, migration, invasion …
3′ UTR heterogeneity and cancer progression
JJ Chan, H Tabatabaeian, Y Tay - Trends in Cell Biology, 2023 - cell.com
The majority of human mRNAs generate alternative 3′ untranslated regions (UTRs)
through various processes, including RNA modifications such as RNA editing, m 6 A …
through various processes, including RNA modifications such as RNA editing, m 6 A …
ADAR1 and its implications in cancer development and treatment
AR Baker, FJ Slack - Trends in Genetics, 2022 - cell.com
The family of adenosine deaminases acting on RNA (ADARs) regulates global gene
expression output by catalyzing adenosine-to-inosine (A-to-I) editing of double-stranded …
expression output by catalyzing adenosine-to-inosine (A-to-I) editing of double-stranded …
Reversal of malignant ADAR1 splice isoform switching with Rebecsinib
Adenosine deaminase acting on RNA1 (ADAR1) preserves genomic integrity by preventing
retroviral integration and retrotransposition during stress responses. However, inflammatory …
retroviral integration and retrotransposition during stress responses. However, inflammatory …
Low RNA stability signifies increased post-transcriptional regulation of cell identity genes
Cell identity genes are distinct from other genes with respect to the epigenetic mechanisms
to activate their transcription, eg by super-enhancers and broad H3K4me3 domains …
to activate their transcription, eg by super-enhancers and broad H3K4me3 domains …
Cellular RNA surveillance in health and disease
The numerous quality control pathways that target defective ribonucleic acids (RNAs) for
degradation play key roles in sha** mammalian transcriptomes and preventing disease …
degradation play key roles in sha** mammalian transcriptomes and preventing disease …
Human MYC G-quadruplex: From discovery to a cancer therapeutic target
W Wang, S Hu, Y Gu, Y Yan, DB Stovall, D Li… - Biochimica et Biophysica …, 2020 - Elsevier
Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …