Widespread use of embryonic and adult stem cells for therapeutic applications will require
reproducible production of large numbers of well-characterized cells under well-controlled …

Nanogels have piqued the interest of researchers as nanoscopic drug delivery systems,
especially for site-specific or time-controlled delivery of therapeutic mediators. A wide range …

Diabetes mellitus is associated with defects in islet β-cell functioning and consequent
hyperglycemia resulting in multi-organ damage. Physiologically relevant models that mimic …

Improved protocols/devices for in vitro culture of 3D cell spheroids may provide essential
cues for proper growth and differentiation of stem/progenitor cells (S/PCs) in their niche …

For β-cell replacement therapies, one challenge is the manufacturing of enough β-cells
(Edmonton protocol for islet transplantation requires 0.5–1× 106 islet equivalents). To …

Cells from primary islets and beta-cell lines form pseudoislets (PIs) in static cultures.
Interestingly, MIN6 beta-cells with aberrant regulation of proliferation form PIs which cease …

Diabetes is a prominent health problem caused by the failure of pancreatic beta cells. One
therapeutic approach is the transplantation of functional beta cells, but it is difficult to …

Insulin-dependent diabetes mellitus or type 1 diabetes mellitus (T1DM) is an auto-immune
condition characterized by the loss of pancreatic β-cells. The curative approach for highly …

Adult pluripotent stem cells are a cellular resource representing unprecedented potential for
cell therapy and tissue engineering. Complementary to this promise, there is a need for …

Gel‐matrix culture environments provide tissue engineering scaffolds and cues that guide
cell differentiation. For many cellular therapy applications such as for the production of islet …