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Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease
H Lee, RV Pearse, AM Lish, C Pan, ZM Augur… - Glia, 2024 - Wiley Online Library
Reactive astrocytes are associated with Alzheimer's disease (AD), and several AD genetic
risk variants are associated with genes highly expressed in astrocytes. However, the …
risk variants are associated with genes highly expressed in astrocytes. However, the …
Label-free electrochemical biosensor with magnetic self-assembly constructed via PNA-DNA hybridization process on α-Fe2O3/Fe3O4 nanosheets for APOE ε4 genes …
Z Xu, Z Lv, H Yang, J Zhang, Z Sun, D He, R Liu - Bioelectrochemistry, 2025 - Elsevier
A label-free electrochemical DNA detection strategy based on self-assembled α-Fe 2 O 3/Fe
3 O 4 nanosheets with PNA-DNA hybridization process was developed for ultrasensitive …
3 O 4 nanosheets with PNA-DNA hybridization process was developed for ultrasensitive …
[HTML][HTML] The impact of APOE4 on neurological symptoms after exposure to K. brevis neurotoxin
GJ Aldrich, A Nkiliza, S Ferguson, D Niedospial… - Environmental …, 2025 - Elsevier
Abstract Introduction The harmful alga Karenia brevis (K. brevis) releases brevetoxins
(PbTx) that cause respiratory and neurological symptoms. The apolipoprotein E (APOE) ε4 …
(PbTx) that cause respiratory and neurological symptoms. The apolipoprotein E (APOE) ε4 …
[HTML][HTML] Leveraging Single-Cell RNA-Seq to Generate Robust Microglia Aging Clocks
'Biological aging clocks'-composite molecular markers thought to capture an individual's
biological age-have been traditionally developed through bulk-level analyses of mixed cells …
biological age-have been traditionally developed through bulk-level analyses of mixed cells …
[HTML][HTML] APOE4 carriers display loss of anticipatory cerebral vascular regulation over AD progression
JA Palmer, CS Kaufman, AA Whitaker-Hilbig… - medRxiv, 2024 - pmc.ncbi.nlm.nih.gov
INTRODUCTION: Maintenance of cerebral blood flow during orthostasis is impaired with
aging and associated with cognitive decline, but the effect of Apolipoprotein 4-allele …
aging and associated with cognitive decline, but the effect of Apolipoprotein 4-allele …
[CITATION][C] Microglial APOE4 promotes neuron degeneration in Alzheimer's disease through inhibition of lipid droplet autophagy
M Mao, X Ma, X Wang, J Ye - Acta Pharmaceutica Sinica B, 2024 - Elsevier