Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer
Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …
[HTML][HTML] Brain-derived neurotrophic factor signaling in depression and antidepressant action
Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …
associated with depression and antidepressant drug action. A variety of preclinical and …
The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology
Background Childhood maltreatment has been linked to a variety of changes in brain
structure and function and stress–responsive neurobiological systems. Epidemiological …
structure and function and stress–responsive neurobiological systems. Epidemiological …
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but
the functional importance of this phenomenon remains unclear. Here, using genetic and …
the functional importance of this phenomenon remains unclear. Here, using genetic and …
Cognitive and affective development in adolescence
L Steinberg - Trends in cognitive sciences, 2005 - cell.com
Questions about the nature of normative and atypical development in adolescence have
taken on special significance in the last few years, as scientists have begun to recast old …
taken on special significance in the last few years, as scientists have begun to recast old …
[HTML][HTML] Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …
antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase …
Neurobiology of depression
Current treatments for depression are inadequate for many individuals, and progress in
understanding the neurobiology of depression is slow. Several promising hypotheses of …
understanding the neurobiology of depression is slow. Several promising hypotheses of …
A neurotrophic model for stress-related mood disorders
There is a growing body of evidence demonstrating that stress decreases the expression of
brain-derived neurotrophic factor (BDNF) in limbic structures that control mood and that …
brain-derived neurotrophic factor (BDNF) in limbic structures that control mood and that …
[BOOK][B] Synaptic self: How our brains become who we are
J LeDoux - 2003 - books.google.com
In 1996 Joseph LeDoux's The Emotional Brain presented a revelatory examination of the
biological bases of our emotions and memories. Now, the world-renowned expert on the …
biological bases of our emotions and memories. Now, the world-renowned expert on the …
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Recent studies suggest that stress-induced atrophy and loss of hippocampal neurons may
contribute to the pathophysiology of depression. The aim of this study was to investigate the …
contribute to the pathophysiology of depression. The aim of this study was to investigate the …