The mammalian lung´ s structural design is optimized to serve its main function: gas
exchange. It takes place in the alveolar region (parenchyma) where air and blood are …

Activation of TGF-β1 initiates a program of temporary collagen accumulation important to
wound repair in many organs. However, the outcome of temporary extracellular matrix …

While the coronavirus disease 19 (COVID-19) pandemic has transformed the medical and
scientific communites since it was first reported in late 2019, we are only beginning to …

Introduction: Transbronchial lung cryobiopsy (TBLC) is increasingly being used as an
alternative to video-assisted thoracoscopic surgery (VATS) biopsy to establish the …

Pulmonary fibrosis (PF) is a progressive, and life-threatening interstitial lung disease which
causes scarring in the lung parenchyma and thereby affects architecture and functioning of …

Mechanical ventilation applies physical stresses to the tissues of the lung and thus may give
rise to ventilator-induced lung injury (VILI), particular in patients with acute respiratory …

Interstitial lung disease (ILD) and pulmonary fibrosis comprise a wide array of inflammatory
and fibrotic lung diseases which are often confusing to general medicine and pulmonary …

Rationale: To improve disease outcomes in idiopathic pulmonary fibrosis (IPF), it is essential
to understand its early pathophysiology so that it can be targeted therapeutically. Objectives …

Mortality in acute respiratory distress syndrome (ARDS) remains unacceptably high at
approximately 39%. One of the only treatments is supportive: mechanical ventilation …

Many lung diseases result in fibrotic remodelling. Fibrotic lung disorders can be divided into
diseases with known and unknown aetiology. Among those with unknown aetiology …