Pathogenesis of celiac disease and other gluten related disorders in wheat and strategies for mitigating them

N Sharma, S Bhatia, V Chunduri, S Kaur… - Frontiers in …, 2020 - frontiersin.org
Wheat is a major cereal crop providing energy and nutrients to the billions of people around
the world. Gluten is a structural protein in wheat, that is necessary for its dough making …

Celiac disease: a review of current concepts in pathogenesis, prevention, and novel therapies

JA Tye-Din, HJ Galipeau, D Agardh - Frontiers in pediatrics, 2018 - frontiersin.org
Our understanding of celiac disease and how it develops has evolved significantly over the
last half century. Although traditionally viewed as a pediatric illness characterized by …

Celiac disease: prevalence, diagnosis, pathogenesis and treatment

N Gujral, HJ Freeman… - World journal of …, 2012 - pmc.ncbi.nlm.nih.gov
Celiac disease (CD) is one of the most common diseases, resulting from both environmental
(gluten) and genetic factors [human leukocyte antigen (HLA) and non-HLA genes]. The …

Properties of gluten intolerance: gluten structure, evolution, pathogenicity and detoxification capabilities

AV Balakireva, AA Zamyatnin Jr - Nutrients, 2016 - mdpi.com
Theterm gluten intolerance may refer to three types of human disorders: autoimmune celiac
disease (CD), allergy to wheat and non-celiac gluten sensitivity (NCGS). Gluten is a mixture …

Current and emerging therapies for coeliac disease

L Kivelä, A Caminero, DA Leffler… - Nature reviews …, 2021 - nature.com
Coeliac disease is a common enteropathy that occurs in genetically susceptible individuals
in response to the ingestion of gluten proteins present in wheat, rye and barley. Currently …

New developments in celiac disease treatment

MV Machado - International journal of molecular sciences, 2023 - mdpi.com
Celiac disease (CD) is a common autoimmune disease affecting around 1% of the
population. It consists of an immune-mediated enteropathy, triggered by gluten exposure in …

Celiac disease: From pathophysiology to treatment

I Parzanese, D Qehajaj, F Patrinicola… - World journal of …, 2017 - pmc.ncbi.nlm.nih.gov
Celiac disease, also known as “celiac sprue”, is a chronic inflammatory disorder of the small
intestine, produced by the ingestion of dietary gluten products in susceptible people. It is a …

Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease

ML Lähdeaho, K Kaukinen, K Laurila, P Vuotikka… - Gastroenterology, 2014 - Elsevier
Background & Aims Gluten ingestion leads to small intestinal mucosal injury in patients with
celiac disease, necessitating strict life-long exclusion of dietary gluten. Despite adherence to …

The spectrum of celiac disease: epidemiology, clinical aspects and treatment

GJ Tack, WHM Verbeek, MWJ Schreurs… - Nature reviews …, 2010 - nature.com
Celiac disease is a gluten-sensitive enteropathy that affects people of all ages worldwide.
This disease has emerged as a major health-care problem, as advances in diagnostic and …

Celiac disease: mechanisms and emerging therapeutics

HA Besser, C Khosla - Trends in pharmacological sciences, 2023 - cell.com
Celiac disease (CeD) is a widespread, gluten-induced, autoimmune disorder that lacks any
medicinal therapy. Towards the goal of develo** non-dietary treatments for CeD, research …