Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

Importance Imaging biomarkers in Parkinson disease (PD) are increasingly important for
monitoring progression in clinical trials and also have the potential to improve clinical care …

In Parkinson's disease (PD) there is a selective degeneration of neuromelanin-containing
neurons, especially substantia nigra dopaminergic neurons. In humans, neuromelanin …

Parkinson disease (PD) is a progressive disorder characterized by dopaminergic
neurodegeneration in the brain. The development of parkinsonism is preceded by a long …

The motor features of Parkinson's disease (PD) are well known to manifest only when striatal
dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-motor …

Animals live in habitats fraught with a range of environmental challenges to their bodies and
brains. Accordingly, cells and organ systems have evolved stress-responsive signaling …

Background Development of reliable and accurate imaging biomarkers of dopaminergic cell
neurodegeneration is necessary to facilitate therapeutic drug trials in Parkinson's disease …

A meta‐analysis of 142 positron emission tomography and single photon emission
computed tomography studies that have investigated striatal presynaptic dopamine function …

Aging is accompanied by profound changes in the brain's dopamine system that affect
cognitive function. Evidence of powerful individual differences in cognitive aging has …

While current effective therapies are available for the symptomatic control of PD, treatments
to halt the progressive neurodegeneration still do not exist. Loss of dopamine neurons in the …