[HTML][HTML] Brain malignancies: Glioblastoma and brain metastases
Brain, the major organ of the central nervous system controls and processes most of body
activities. Therefore, the most aggressive brain tumor–glioblastoma and metastases from …
activities. Therefore, the most aggressive brain tumor–glioblastoma and metastases from …
Peritoneal metastases from colorectal cancer: defining and addressing the challenges
O Kranenburg, K Speeten, I Hingh - Frontiers in oncology, 2021 - frontiersin.org
The presence of peritoneal metastases (PM) in patients with colorectal cancer (CRC) is
associated with an extremely poor prognosis. The diagnosis of PM is challenging, resulting …
associated with an extremely poor prognosis. The diagnosis of PM is challenging, resulting …
Map** molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities
The molecular events and transcriptional plasticity driving brain metastasis in clinically
relevant breast tumor subtypes has not been determined. Here we comprehensively dissect …
relevant breast tumor subtypes has not been determined. Here we comprehensively dissect …
Genomic evolution and diverse models of systemic metastases in colorectal cancer
Objective The systemic spread of colorectal cancer (CRC) is dominated by the portal system
and exhibits diverse patterns of metastasis without systematical genomic investigation. Here …
and exhibits diverse patterns of metastasis without systematical genomic investigation. Here …
[HTML][HTML] Long-term clinical outcome of trastuzumab and lapatinib for HER2-positive metastatic colorectal cancer
Background ERBB2 amplification occurs in 5% of RAS wild-type metastatic colorectal
cancer (mCRC) and it has been shown to be a target for treatment with 2 HER2-directed …
cancer (mCRC) and it has been shown to be a target for treatment with 2 HER2-directed …
Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in cutaneous T-cell lymphoma
T-cell non-Hodgkin's lymphomas develop following transformation of tissue resident T-cells.
We performed a meta-analysis of whole exome sequencing data from 403 patients with …
We performed a meta-analysis of whole exome sequencing data from 403 patients with …
Lonicera caerulea L. Polyphenols Alleviate Oxidative Stress‐Induced Intestinal Environment Imbalance and Lipopolysaccharide‐Induced Liver Injury in HFD‐Fed …
B Li, Z Cheng, X Sun, X Si, E Gong… - Molecular nutrition & …, 2020 - Wiley Online Library
Scope This study investigates the modulatory effects of Lonicera caerulea L. polyphenols
(LCPs) on the intestinal environment and lipopolysaccharide (LPS)‐induced liver injury via …
(LCPs) on the intestinal environment and lipopolysaccharide (LPS)‐induced liver injury via …
Discordance of immunotherapy response predictive biomarkers between primary lesions and paired metastases in tumours: A systematic review and meta-analysis
Y Zou, X Hu, S Zheng, A Yang, X Li, H Tang, Y Kong… - …, 2021 - thelancet.com
Background Several biomarkers predict the efficacy of immunotherapy, which is essential for
selecting patients who would potentially benefit. Discordant status of these biomarkers …
selecting patients who would potentially benefit. Discordant status of these biomarkers …
ATM-inhibitor AZD1390 is a radiosensitizer for breast cancer CNS metastasis
Purpose: Limited effective treatments are currently available for central nervous system
(CNS) metastasis (CM). This is largely driven by the inability of current therapeutics to …
(CNS) metastasis (CM). This is largely driven by the inability of current therapeutics to …
Growth exponents reflect evolutionary processes and treatment response in brain metastases
Tumor growth is the result of the interplay of complex biological processes in huge numbers
of individual cells living in changing environments. Effective simple mathematical laws have …
of individual cells living in changing environments. Effective simple mathematical laws have …