RAS genes (HRAS, KRAS, and NRAS) comprise the most frequently mutated oncogene
family in human cancer. With the highest RAS mutation frequencies seen with the top three …

Pancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor
prognosis can be attributed to both troublesome detections at the initial stage, which makes …

We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …

Objective: The aim of the study was to identify the survival of patients with locally advanced
pancreatic cancer (LAPC) and assess the effect of surgical resection after neoadjuvant …

The mechanisms responsible for radioresistance in pancreatic cancer have yet to be
elucidated, and the suppressive tumor immune microenvironment must be considered. We …

Clinically relevant subtypes exist for pancreatic ductal adenocarcinoma (PDAC), but
molecular characterization is not yet standard in clinical care. We implemented a biopsy …

Circular RNA (circ-RNA) and exosomes have recently been shown to play important roles in
different tumors. However, the functions and regulatory mechanisms of exosomal circ-RNA …

Objectives: To establish an evidence-based cut-off to differentiate between early and late
recurrence and to compare clinicopathologic risk factors between the two groups. Summary …

Cancer-associated fibroblasts (CAF) may exert tumor-promoting and tumor-suppressive
functions, but the mechanisms underlying these opposing effects remain elusive. Here, we …

Charged particle therapy is generally regarded as cutting-edge technology in oncology.
Many proton therapy centres are active in the USA, Europe, and Asia, but only a few centres …