Disease modification in inflammatory skin disorders: opportunities and challenges

T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

The trinity of skin: skin homeostasis as a neuro–endocrine–immune organ

R **, L Luo, J Zheng - Life, 2022 - mdpi.com
For a long time, skin was thought to be no more than the barrier of our body. However, in the
last few decades, studies into the idea of skin as an independent functional organ have …

Biomarkers of subclinical atherosclerosis in patients with psoriasis

H Kaiser, X Wang, A Kvist-Hansen, M Krakauer… - Scientific reports, 2021 - nature.com
Psoriasis is linked with increased risk of cardiovascular disease (CVD) that is
underestimated by traditional risk stratification. We conducted a large-scale plasma …

Dynamic trafficking patterns of IL-17-producing γδ T cells are linked to the recurrence of skin inflammation in psoriasis-like dermatitis

N Liu, H Qin, Y Cai, X Li, L Wang, Q Xu, F Xue… - …, 2022 - thelancet.com
Background Psoriasis recurrence is a clinically challenging issue. However, the underlying
mechanisms haven't been fully understood. Methods RNAseq analysis from affected skin of …

NF-κB and its crosstalk with endoplasmic reticulum stress in atherosclerosis

W Li, K **, J Luo, W Xu, Y Wu, J Zhou… - Frontiers in …, 2022 - frontiersin.org
Atherosclerosis (AS) is a common cardiovascular disease with complex pathogenesis, in
which multiple pathways and their interweaving regulatory mechanism remain unclear. The …

Multi-Omics research strategies for psoriasis and atopic dermatitis

Y Guo, L Luo, J Zhu, C Li - International Journal of Molecular Sciences, 2023 - mdpi.com
Psoriasis and atopic dermatitis (AD) are multifactorial and heterogeneous inflammatory skin
diseases, while years of research have yielded no cure, and the costs associated with caring …

The impact of psoriasis and atopic dermatitis on quality of life: a literature research on biomarkers

A Balato, A Zink, G Babino, D Buononato, C Kiani… - Life, 2022 - mdpi.com
Psoriasis (PSO) and Atopic dermatitis (AD) are common inflammatory skin diseases that
affect people of all ages globally. They negatively impact the quality of life (QoL) of patients …

Large‐scale serum analysis identifies unique systemic biomarkers in psoriasis and hidradenitis suppurativa

K Navrazhina, Y Renert‐Yuval, JW Frew… - British Journal of …, 2022 - academic.oup.com
Background Hidradenitis suppurativa (HS) is now recognized as a systemic inflammatory
disease, sharing molecular similarities with psoriasis. Direct comparison of the systemic …

Allicin ameliorates imiquimod‐induced psoriasis‐like skin inflammation via disturbing the interaction of keratinocytes with IL‐17A

L Zhang, X Ma, R Shi, L Zhang, R Zhao… - British Journal of …, 2023 - Wiley Online Library
Background and Purpose Psoriasis is an inflammatory skin disease of chronic recurrence
mediated by the interaction between IL‐17 and keratinocytes, which sustains a vicious circle …

Ustekinumab reduces serum protein levels associated with cardiovascular risk in psoriasis vulgaris

M Koschitzky, K Navrazhina… - Experimental …, 2022 - Wiley Online Library
Psoriasis increases the risk of cardiovascular disease (CVD). Biomarkers for cardiovascular
(CV) risk stratification in psoriasis are lacking, and the effects of psoriasis biologics on CV …